Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 889008..889537 Replicon chromosome
Accession NZ_CP035288
Organism Staphylococcus epidermidis strain ATCC 14990

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag EQW00_RS04340 Protein ID WP_001829891.1
Coordinates 889175..889537 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag EQW00_RS04335 Protein ID WP_001829931.1
Coordinates 889008..889178 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQW00_RS04310 884832..885311 + 480 WP_002457111.1 PH domain-containing protein -
EQW00_RS04315 885304..886809 + 1506 WP_002457110.1 PH domain-containing protein -
EQW00_RS04320 886796..887305 + 510 WP_002457109.1 PH domain-containing protein -
EQW00_RS04325 887353..887706 + 354 WP_002457108.1 holo-ACP synthase -
EQW00_RS04330 887773..888921 + 1149 WP_002457107.1 alanine racemase -
EQW00_RS04335 889008..889178 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EQW00_RS04340 889175..889537 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQW00_RS04345 889882..890883 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
EQW00_RS04350 890983..891309 + 327 WP_001829952.1 anti-sigma factor antagonist -
EQW00_RS04355 891311..891790 + 480 WP_001829903.1 anti-sigma B factor RsbW -
EQW00_RS04360 891765..892535 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T117545 WP_001829891.1 NZ_CP035288:889175-889537 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T117545 NZ_CP035288:889175-889537 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT117545 WP_001829931.1 NZ_CP035288:889008-889178 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT117545 NZ_CP035288:889008-889178 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References