Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 877823..878332 Replicon chromosome
Accession NZ_CP035288
Organism Staphylococcus epidermidis strain ATCC 14990

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag EQW00_RS04280 Protein ID WP_001829980.1
Coordinates 878123..878332 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag EQW00_RS04275 Protein ID WP_001829893.1
Coordinates 877823..878116 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQW00_RS04250 872831..873619 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
EQW00_RS04255 873625..874263 + 639 WP_002505076.1 thiamine phosphate synthase -
EQW00_RS04260 874352..875224 + 873 WP_002470121.1 membrane protein insertase YidC -
EQW00_RS04265 875330..875983 - 654 WP_001829983.1 HD domain-containing protein -
EQW00_RS04270 876165..877649 - 1485 WP_002457116.1 cardiolipin synthase -
EQW00_RS04275 877823..878116 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
EQW00_RS04280 878123..878332 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
EQW00_RS04285 878475..878612 + 138 WP_001829949.1 hypothetical protein -
EQW00_RS04290 878711..879922 - 1212 WP_002486299.1 rod shape-determining protein RodA -
EQW00_RS04295 880313..881386 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
EQW00_RS04300 881398..882753 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T117544 WP_001829980.1 NZ_CP035288:878123-878332 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T117544 NZ_CP035288:878123-878332 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT117544 WP_001829893.1 NZ_CP035288:877823-878116 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT117544 NZ_CP035288:877823-878116 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References