Detailed information of TA system TA117543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 50623..51160
• Replicon: plasmid pTAV1
• Accession: NZ_CP035285
• Organism: Paracoccus versutus strain UW1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQ718_RS14070
• Protein ID: WP_116171358.1
• Coordinates: 50858..51160 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EQ718_RS14065
• Protein ID: WP_104491151.1
• Coordinates: 50623..50868 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ718_RS14035	46557..46955	+	399	WP_116171364.1	DUF3768 domain-containing protein	-
EQ718_RS14040 (EQ718_13955)	47209..49029	+	1821	WP_116171363.1	ParB/RepB/Spo0J family partition protein	-
EQ718_RS14045 (EQ718_13960)	49077..49523	+	447	WP_116171362.1	hypothetical protein	-
EQ718_RS14050 (EQ718_13965)	49516..49749	+	234	WP_116171361.1	hypothetical protein	-
EQ718_RS14055 (EQ718_13970)	49752..50081	+	330	WP_116171360.1	hypothetical protein	-
EQ718_RS14060 (EQ718_13975)	50305..50601	+	297	WP_116171359.1	hypothetical protein	-
EQ718_RS14065 (EQ718_13980)	50623..50868	+	246	WP_104491151.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EQ718_RS14070 (EQ718_13985)	50858..51160	+	303	WP_116171358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQ718_RS14075 (EQ718_13990)	51623..51817	+	195	WP_116171357.1	hypothetical protein	-
EQ718_RS14080	51819..51992	-	174	WP_166436162.1	hypothetical protein	-
EQ718_RS14085 (EQ718_13995)	51989..52171	-	183	WP_116171356.1	hypothetical protein	-
EQ718_RS14090 (EQ718_14000)	52181..52606	-	426	WP_166436161.1	type II toxin-antitoxin system VapC family toxin	-
EQ718_RS14095 (EQ718_14005)	52606..52851	-	246	WP_166436160.1	type II toxin-antitoxin system VapB family antitoxin	-
EQ718_RS14100 (EQ718_14010)	53480..53677	+	198	WP_140848564.1	hypothetical protein	-
EQ718_RS14105 (EQ718_14015)	54435..54668	+	234	WP_116171387.1	hypothetical protein	-
EQ718_RS14110 (EQ718_14020)	54607..55323	+	717	WP_166436173.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..104578	104578

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11640.48 Da
• Isoelectric Point: 10.7228

>T117543 WP_116171358.1 NZ_CP035285:50858-51160 [Paracoccus versutus]
MTFELKFLPSALKEWKKLGATLREQFRKKLAERLEQPRVPADALHGLEDHYKIKLRSAGYRLVYRVENAEITVTVVAVGR
RERSEVYKAASARRDDRPKS

Nucleotide

• Length: 303 bp

>T117543 NZ_CP035285:50858-51160 [Paracoccus versutus]
ATGACCTTTGAGCTTAAGTTCCTGCCATCCGCACTGAAGGAGTGGAAAAAGCTCGGTGCCACGCTTCGGGAGCAGTTTCG
GAAGAAGCTGGCCGAACGTCTGGAGCAGCCCCGTGTTCCTGCTGATGCGCTGCATGGTCTGGAAGATCATTACAAGATCA
AGCTCCGCAGCGCCGGCTACCGACTCGTCTATCGCGTGGAGAATGCAGAAATTACCGTCACTGTGGTCGCAGTTGGTCGT
CGAGAACGAAGCGAGGTGTATAAAGCAGCAAGCGCACGGCGCGATGATCGACCCAAAAGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8844.18 Da
• Isoelectric Point: 4.1265

>AT117543 WP_104491151.1 NZ_CP035285:50623-50868 [Paracoccus versutus]
MQRVEAQIAVSVSDLKKSPTAIMDQAQGEAVAVLNHNRVMAYMVPADVYEAMMERLDDLALVDVIKARADETPISVGLDD
L

Nucleotide

• Length: 246 bp

>AT117543 NZ_CP035285:50623-50868 [Paracoccus versutus]
ATGCAACGTGTTGAAGCCCAGATTGCGGTCAGTGTCTCTGATCTGAAGAAAAGCCCGACCGCCATCATGGATCAGGCGCA
AGGCGAGGCCGTCGCCGTGCTGAACCACAATCGCGTCATGGCTTATATGGTCCCGGCCGATGTTTACGAGGCGATGATGG
AGCGGCTGGACGACCTGGCGCTTGTCGATGTTATTAAGGCCCGGGCGGATGAAACGCCGATCAGCGTGGGCCTCGATGAC
CTTTGA