Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 23959..24515 Replicon chromosome
Accession NZ_CP035284
Organism Paracoccus versutus strain UW1

Toxin (Protein)


Gene name vapC Uniprot ID A0A3E0BLJ9
Locus tag EQ718_RS00155 Protein ID WP_036757516.1
Coordinates 24150..24515 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3E0BNE0
Locus tag EQ718_RS00150 Protein ID WP_036757591.1
Coordinates 23959..24153 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ718_RS00120 (EQ718_00130) 19477..20466 - 990 WP_275600368.1 iron ABC transporter permease -
EQ718_RS00125 (EQ718_00135) 21026..21607 - 582 WP_072463115.1 ABC transporter substrate-binding protein -
EQ718_RS00130 (EQ718_00140) 21621..21800 - 180 Protein_25 ATP-binding cassette domain-containing protein -
EQ718_RS00135 (EQ718_00145) 21797..22138 - 342 WP_208021387.1 iron chelate uptake ABC transporter family permease subunit -
EQ718_RS00140 (EQ718_00150) 22125..22562 - 438 Protein_27 TonB-dependent receptor -
EQ718_RS00145 (EQ718_00155) 22589..23752 - 1164 Protein_28 IncP-type conjugal transfer protein TraG -
EQ718_RS00150 (EQ718_00160) 23959..24153 + 195 WP_036757591.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EQ718_RS00155 (EQ718_00165) 24150..24515 + 366 WP_036757516.1 type II toxin-antitoxin system VapC family toxin Toxin
EQ718_RS00160 (EQ718_00170) 24519..25052 + 534 WP_036757518.1 isochorismatase family protein -
EQ718_RS00165 (EQ718_00175) 25128..25457 + 330 WP_036757520.1 hypothetical protein -
EQ718_RS00170 (EQ718_00180) 25464..27235 - 1772 Protein_33 DUF3363 domain-containing protein -
EQ718_RS00175 (EQ718_00185) 27484..28065 - 582 WP_036757522.1 hypothetical protein -
EQ718_RS00180 (EQ718_00190) 28115..28435 - 321 WP_243700263.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13024.13 Da        Isoelectric Point: 5.9611

>T117540 WP_036757516.1 NZ_CP035284:24150-24515 [Paracoccus versutus]
VILVDTSIWIDHLRAGDTELVDLLNAEQVLAHPFIIGELALGSLKDRETVIAAMQGLPQAPVASHAEVMALIDARRLFSL
GIGYVDAHLIAATLLAPGTTLWTRDRRLSAAAKHIDFPPKG

Download         Length: 366 bp

>T117540 NZ_CP035284:24150-24515 [Paracoccus versutus]
GTGATCCTCGTCGACACCTCGATCTGGATCGACCATCTACGCGCGGGCGATACGGAACTGGTCGATCTCCTGAACGCCGA
ACAGGTGCTGGCGCATCCCTTCATCATCGGCGAGTTGGCGCTCGGCAGCCTCAAGGACCGGGAAACCGTCATCGCCGCGA
TGCAGGGCCTGCCGCAGGCGCCCGTGGCCAGCCATGCCGAGGTGATGGCATTGATCGACGCGCGGCGGCTTTTCAGCCTC
GGCATCGGCTATGTCGATGCGCATCTGATCGCCGCCACCCTGCTCGCCCCCGGCACCACGCTCTGGACCCGCGACCGTCG
CCTGAGCGCGGCAGCAAAACACATCGACTTTCCTCCGAAAGGATGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7051.10 Da        Isoelectric Point: 8.9774

>AT117540 WP_036757591.1 NZ_CP035284:23959-24153 [Paracoccus versutus]
MRTTLNLDDELLQQARELTGIGEKAVLVREGLKALIERESARRLALLGGTDERASVAPRRQPAP

Download         Length: 195 bp

>AT117540 NZ_CP035284:23959-24153 [Paracoccus versutus]
ATGCGCACGACCCTGAACCTCGATGACGAGTTGCTCCAGCAGGCCCGCGAGCTCACCGGCATCGGCGAGAAGGCCGTTCT
GGTGCGCGAGGGGCTGAAGGCCCTGATCGAGCGCGAGAGCGCCCGGCGGCTCGCCCTGCTCGGCGGCACCGACGAGCGGG
CCTCGGTGGCCCCGCGGCGGCAGCCGGCGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3E0BLJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A3E0BNE0

References