Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4452169..4452872 Replicon chromosome
Accession NZ_CP035276
Organism Citrobacter freundii strain R17

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag EQ249_RS21870 Protein ID WP_106107568.1
Coordinates 4452169..4452510 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EQ249_RS21875 Protein ID WP_106107569.1
Coordinates 4452546..4452872 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ249_RS21840 4448187..4448549 + 363 WP_106107563.1 endoribonuclease SymE -
EQ249_RS21845 4448708..4449580 + 873 WP_106107564.1 HNH endonuclease -
EQ249_RS21850 4449710..4450498 - 789 WP_106107565.1 helix-turn-helix domain-containing protein -
EQ249_RS21855 4450617..4450892 - 276 WP_106107566.1 type II toxin-antitoxin system RelE/ParE family toxin -
EQ249_RS21860 4450896..4451144 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein -
EQ249_RS21865 4451221..4452054 - 834 WP_106107567.1 DUF4942 domain-containing protein -
EQ249_RS21870 4452169..4452510 - 342 WP_106107568.1 TA system toxin CbtA family protein Toxin
EQ249_RS21875 4452546..4452872 - 327 WP_106107569.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EQ249_RS21880 4452917..4453390 - 474 WP_106107570.1 DNA repair protein RadC -
EQ249_RS21885 4453461..4454282 - 822 WP_106107571.1 DUF945 domain-containing protein -
EQ249_RS21890 4454355..4454804 - 450 WP_106107572.1 hypothetical protein -
EQ249_RS21900 4455048..4455851 - 804 WP_106108128.1 hypothetical protein -
EQ249_RS21905 4455871..4456233 - 363 Protein_4201 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12899.88 Da        Isoelectric Point: 7.8846

>T117533 WP_106107568.1 NZ_CP035276:c4452510-4452169 [Citrobacter freundii]
MKTLPASTQRAAKPCPTPVVVWQTLLTLLLEQHYGLTLNDTPFCDETVIQEHINAGITLADAVNFLVEKYELIRIDRRGF
SWQEQSPYLRAVDILRARQATGLLRQSHNLLTR

Download         Length: 342 bp

>T117533 NZ_CP035276:c4452510-4452169 [Citrobacter freundii]
ATGAAAACTTTACCTGCATCAACTCAGCGGGCGGCTAAGCCATGCCCGACGCCCGTAGTTGTCTGGCAAACGCTACTCAC
CCTTCTGCTGGAGCAACACTATGGTCTGACTCTGAACGACACGCCATTCTGCGATGAAACAGTCATTCAGGAACATATTA
ACGCCGGTATCACACTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGATTCGTATCGATCGCAGAGGGTTT
AGCTGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGATATTTTGCGGGCGAGACAGGCAACTGGTCTGTTGCGACAAAG
CCATAATCTTTTGACACGCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12349.98 Da        Isoelectric Point: 5.5564

>AT117533 WP_106107569.1 NZ_CP035276:c4452872-4452546 [Citrobacter freundii]
MEKNDPIEWGLRRDITPRVGARLVQEGNQLHYLADRAGVTGIFNEAESRKLNAAFPHFVEQMELMLLSGELNPRYAHCVT
LYHDGFTCEADTLGSYGYVYIVIYPTQR

Download         Length: 327 bp

>AT117533 NZ_CP035276:c4452872-4452546 [Citrobacter freundii]
ATGGAGAAAAACGATCCCATCGAATGGGGGCTTCGACGCGATATCACGCCGCGTGTAGGAGCACGACTGGTACAGGAAGG
AAATCAATTGCATTACCTGGCTGACCGGGCCGGTGTCACCGGCATTTTTAATGAAGCTGAGAGCCGCAAACTGAATGCAG
CATTTCCGCATTTCGTGGAGCAGATGGAGTTAATGCTACTCTCCGGGGAACTAAACCCCCGTTATGCACATTGTGTCACC
CTGTACCATGATGGATTTACCTGCGAAGCTGACACGCTTGGCTCTTATGGTTACGTCTACATCGTCATTTACCCCACTCA
ACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References