Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4450617..4451144 Replicon chromosome
Accession NZ_CP035276
Organism Citrobacter freundii strain R17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EQ249_RS21855 Protein ID WP_106107566.1
Coordinates 4450617..4450892 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A941UEC5
Locus tag EQ249_RS21860 Protein ID WP_000535213.1
Coordinates 4450896..4451144 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ249_RS21835 4446038..4447408 - 1371 WP_003837154.1 tyrosine phenol-lyase -
EQ249_RS21840 4448187..4448549 + 363 WP_106107563.1 endoribonuclease SymE -
EQ249_RS21845 4448708..4449580 + 873 WP_106107564.1 HNH endonuclease -
EQ249_RS21850 4449710..4450498 - 789 WP_106107565.1 helix-turn-helix domain-containing protein -
EQ249_RS21855 4450617..4450892 - 276 WP_106107566.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQ249_RS21860 4450896..4451144 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein Antitoxin
EQ249_RS21865 4451221..4452054 - 834 WP_106107567.1 DUF4942 domain-containing protein -
EQ249_RS21870 4452169..4452510 - 342 WP_106107568.1 TA system toxin CbtA family protein -
EQ249_RS21875 4452546..4452872 - 327 WP_106107569.1 type IV toxin-antitoxin system YeeU family antitoxin -
EQ249_RS21880 4452917..4453390 - 474 WP_106107570.1 DNA repair protein RadC -
EQ249_RS21885 4453461..4454282 - 822 WP_106107571.1 DUF945 domain-containing protein -
EQ249_RS21890 4454355..4454804 - 450 WP_106107572.1 hypothetical protein -
EQ249_RS21900 4455048..4455851 - 804 WP_106108128.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11027.41 Da        Isoelectric Point: 4.8888

>T117532 WP_106107566.1 NZ_CP035276:c4450892-4450617 [Citrobacter freundii]
MEVYWTLKAQDDLERIYRFALQYSRQHADDVLDRLIIGCAGLTAHPAIGIQQTRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T117532 NZ_CP035276:c4450892-4450617 [Citrobacter freundii]
ATGGAAGTTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACCGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGCCGATGACGTTTTGGATCGCCTGATTATTGGCTGTGCTGGTCTTACAGCGCATCCGGCAATTGGCATACAGCAGACGC
GGTATGAACCTCGTGAGGTCCGAAAAGTGTTATTCGATGACTATGAGGTTCACTACGAACTCCGTGACAATGATATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9004.31 Da        Isoelectric Point: 7.2042

>AT117532 WP_000535213.1 NZ_CP035276:c4451144-4450896 [Citrobacter freundii]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
KS

Download         Length: 249 bp

>AT117532 NZ_CP035276:c4451144-4450896 [Citrobacter freundii]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCCGTTGAGTTGGCTGCTGCTGTTGAAAATCTGGCAATTGA
GTTGGACCGTTCTAAGAGCTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCACCAGAGTA
TCCAGGCCGGTCTTGCCGATGTGGATGCCGGTCGCGTGGTGAGCCACTCGGATATGGTAGATTTTGCTAATCGCTTAAAG
AAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References