117514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1125245..1125743 Replicon chromosome
Accession NZ_CP035265
Organism Streptococcus pneumoniae strain TVO_1901920

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQH15_RS05685 Protein ID WP_001823540.1
Coordinates 1125245..1125499 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH15_RS05690 Protein ID WP_000208080.1
Coordinates 1125501..1125743 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH15_RS05670 (EQH15_05970) 1120506..1122974 - 2469 WP_001152992.1 DNA gyrase subunit A -
EQH15_RS05675 (EQH15_05975) 1123168..1124154 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH15_RS05680 (EQH15_05980) 1124503..1125198 - 696 WP_000731163.1 potassium channel family protein -
EQH15_RS05685 (EQH15_05985) 1125245..1125499 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH15_RS05690 (EQH15_05990) 1125501..1125743 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH15_RS05695 (EQH15_05995) 1125834..1126643 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH15_RS05700 (EQH15_06000) 1126645..1127994 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH15_RS05705 (EQH15_06005) 1127987..1128691 - 705 WP_000722076.1 response regulator YycF -
EQH15_RS05710 (EQH15_06010) 1128746..1129921 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
EQH15_RS10845 1130018..1130143 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T117514 WP_001823540.1 NZ_CP035265:c1125499-1125245 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117514 NZ_CP035265:c1125499-1125245 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117514 WP_000208080.1 NZ_CP035265:c1125743-1125501 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117514 NZ_CP035265:c1125743-1125501 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References