117513

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 971138..972375 Replicon chromosome
Accession NZ_CP035265
Organism Streptococcus pneumoniae strain TVO_1901920

Toxin (Protein)


Gene name pezT Uniprot ID Q97QZ1
Locus tag EQH15_RS04985 Protein ID WP_000405360.1
Coordinates 971614..972375 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag EQH15_RS04980 Protein ID WP_000579612.1
Coordinates 971138..971614 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH15_RS04960 (EQH15_05230) 966211..967065 + 855 Protein_986 ADP-ribosylglycohydrolase family protein -
EQH15_RS04965 (EQH15_05235) 967177..968061 + 885 WP_000710115.1 diacylglycerol kinase family lipid kinase -
EQH15_RS04970 (EQH15_05240) 968224..969963 + 1740 WP_000423465.1 glycoside hydrolase family 13 protein -
EQH15_RS04975 (EQH15_05245) 970238..970693 + 456 WP_000500478.1 hypothetical protein -
EQH15_RS04980 (EQH15_05250) 971138..971614 + 477 WP_000579612.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
EQH15_RS04985 (EQH15_05255) 971614..972375 + 762 WP_000405360.1 type II toxin-antitoxin system toxin PezT Toxin
EQH15_RS04990 (EQH15_05260) 972403..973567 + 1165 Protein_992 hypothetical protein -
EQH15_RS04995 (EQH15_05270) 974386..974745 + 360 WP_000003745.1 SAG1252 family conjugative relaxosome accessory protein -
EQH15_RS05000 (EQH15_05275) 974755..975120 + 366 WP_000263049.1 plasmid mobilization relaxosome protein MobC -
EQH15_RS05005 (EQH15_05280) 975107..976972 + 1866 WP_000261795.1 SAG1250 family conjugative relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 962310..976972 14662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29129.20 Da        Isoelectric Point: 7.5087

>T117513 WP_000405360.1 NZ_CP035265:971614-972375 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T117513 NZ_CP035265:971614-972375 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATCGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT117513 WP_000579612.1 NZ_CP035265:971138-971614 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT117513 NZ_CP035265:971138-971614 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAACTAATAGATATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2P5T

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References