117512

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 257949..258483 Replicon chromosome
Accession NZ_CP035265
Organism Streptococcus pneumoniae strain TVO_1901920

Toxin (Protein)


Gene name relE Uniprot ID Q8DRA4
Locus tag EQH15_RS01385 Protein ID WP_000913054.1
Coordinates 258205..258483 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A4I6R2F6
Locus tag EQH15_RS01380 Protein ID WP_000041490.1
Coordinates 257949..258212 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH15_RS01375 (EQH15_01430) 253456..257847 + 4392 WP_000071414.1 PolC-type DNA polymerase III -
EQH15_RS01380 (EQH15_01435) 257949..258212 + 264 WP_000041490.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EQH15_RS01385 (EQH15_01440) 258205..258483 + 279 WP_000913054.1 type II toxin-antitoxin system YafQ family toxin Toxin
EQH15_RS01390 (EQH15_01445) 258504..258656 + 153 WP_000776611.1 hypothetical protein -
EQH15_RS01395 (EQH15_01450) 258678..259919 + 1242 WP_000243916.1 aminopeptidase -
EQH15_RS01400 (EQH15_01455) 259929..260159 + 231 WP_000901566.1 GlsB/YeaQ/YmgE family stress response membrane protein -
EQH15_RS01405 260180..260338 + 159 WP_000692943.1 hypothetical protein -
EQH15_RS01410 (EQH15_01465) 260427..261149 + 723 WP_001855007.1 pseudouridine synthase -
EQH15_RS01415 (EQH15_01475) 261367..262701 + 1335 WP_000991692.1 aminopeptidase C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10960.76 Da        Isoelectric Point: 10.0373

>T117512 WP_000913054.1 NZ_CP035265:258205-258483 [Streptococcus pneumoniae]
VLKIRYHKQFKKDFKLAMKRGLKAELLEEVLNFLVQEKEHPARYRDHSLTASKHFQGVRECHTQPDWLLVYKVDKSELIL
NLLRTGSHSDLF

Download         Length: 279 bp

>T117512 NZ_CP035265:258205-258483 [Streptococcus pneumoniae]
GTGCTTAAGATTCGTTATCATAAACAGTTTAAAAAAGATTTTAAGTTGGCTATGAAGCGTGGTTTGAAGGCAGAATTATT
AGAAGAAGTTTTGAATTTTCTGGTTCAAGAAAAAGAACATCCTGCCAGATATCGTGATCATTCATTGACGGCATCCAAGC
ATTTTCAAGGAGTTCGTGAATGCCATACCCAGCCAGATTGGCTTTTGGTTTATAAAGTAGACAAGTCGGAATTGATTTTA
AATTTGCTGAGGACAGGCAGTCACAGTGATTTATTTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10011.36 Da        Isoelectric Point: 4.3569

>AT117512 WP_000041490.1 NZ_CP035265:257949-258212 [Streptococcus pneumoniae]
MSKMSISIRLDSEVKEQAQQVFSNLGMDITTAINIFLRQAIQYQGLPFDVRLDENRKLLQALTDLDQNRNMSQSFESVSD
LMEDLRA

Download         Length: 264 bp

>AT117512 NZ_CP035265:257949-258212 [Streptococcus pneumoniae]
ATGTCAAAGATGAGTATAAGCATCCGTCTGGATAGTGAGGTTAAGGAGCAGGCCCAACAGGTGTTTAGTAATCTGGGAAT
GGATATAACAACAGCTATTAATATTTTCCTTCGTCAGGCAATTCAATATCAGGGACTACCTTTTGATGTTAGACTAGACG
AAAATCGGAAGTTGCTCCAAGCGTTAACGGATTTAGACCAAAATCGTAATATGAGCCAGTCTTTTGAATCAGTCTCAGAT
TTGATGGAGGACTTACGTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A064C092

Antitoxin

Source ID Structure
AlphaFold DB A0A4I6R2F6

References