Detailed information of TA system TA117511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1654216..1654884
• Replicon: chromosome
• Accession: NZ_CP035264
• Organism: Streptococcus pneumoniae strain TVO_1901921

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C1C927
• Locus tag: EQH16_RS08495
• Protein ID: WP_001132282.1
• Coordinates: 1654705..1654884 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EQH16_RS08490
• Protein ID: WP_000961808.1
• Coordinates: 1654216..1654668 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH16_RS08465 (EQH16_08880)	1650106..1650849	-	744	WP_001188213.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
EQH16_RS08470 (EQH16_08885)	1650851..1651804	-	954	WP_000970781.1	50S ribosomal protein L11 methyltransferase	-
EQH16_RS08475 (EQH16_08890)	1651939..1652367	-	429	WP_000418168.1	NUDIX hydrolase	-
EQH16_RS08480 (EQH16_08895)	1652348..1653436	-	1089	WP_000719722.1	site-2 protease family protein	-
EQH16_RS08485 (EQH16_08900)	1653455..1653925	-	471	WP_000257097.1	DUF3013 family protein	-
EQH16_RS08490 (EQH16_08905)	1654216..1654668	-	453	WP_000961808.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH16_RS08495 (EQH16_08910)	1654705..1654884	-	180	WP_001132282.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH16_RS08500 (EQH16_08915)	1655021..1655200	-	180	WP_001048906.1	hypothetical protein	-
EQH16_RS08505 (EQH16_08925)	1655404..1655604	-	201	WP_000818081.1	hypothetical protein	-
EQH16_RS08510 (EQH16_08935)	1655874..1657145	+	1272	WP_001113212.1	replication-associated recombination protein A	-
EQH16_RS08520 (EQH16_08945)	1657690..1659009	-	1320	WP_000608889.1	glycoside hydrolase family 32 protein	-
EQH16_RS08525 (EQH16_08950)	1659019..1659864	-	846	WP_000819520.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6713.95 Da
• Isoelectric Point: 11.0174

>T117511 WP_001132282.1 NZ_CP035264:c1654884-1654705 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Nucleotide

• Length: 180 bp

>T117511 NZ_CP035264:c1654884-1654705 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16685.54 Da
• Isoelectric Point: 3.7220

>AT117511 WP_000961808.1 NZ_CP035264:c1654668-1654216 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVLEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117511 NZ_CP035264:c1654668-1654216 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATTAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0E7SUI3