Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1160018..1160516 Replicon chromosome
Accession NZ_CP035264
Organism Streptococcus pneumoniae strain TVO_1901921

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQH16_RS05945 Protein ID WP_001823540.1
Coordinates 1160018..1160272 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH16_RS05950 Protein ID WP_000208080.1
Coordinates 1160274..1160516 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH16_RS05930 (EQH16_06230) 1155279..1157747 - 2469 WP_001152992.1 DNA gyrase subunit A -
EQH16_RS05935 (EQH16_06235) 1157941..1158927 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH16_RS05940 (EQH16_06240) 1159276..1160043 - 768 WP_225348254.1 potassium channel family protein -
EQH16_RS05945 (EQH16_06245) 1160018..1160272 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH16_RS05950 (EQH16_06250) 1160274..1160516 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH16_RS05955 (EQH16_06255) 1160607..1161416 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH16_RS05960 (EQH16_06260) 1161418..1162767 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH16_RS05965 (EQH16_06265) 1162760..1163464 - 705 WP_000722076.1 response regulator YycF -
EQH16_RS05970 (EQH16_06270) 1163519..1164694 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
EQH16_RS11125 1164791..1164916 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T117509 WP_001823540.1 NZ_CP035264:c1160272-1160018 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117509 NZ_CP035264:c1160272-1160018 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117509 WP_000208080.1 NZ_CP035264:c1160516-1160274 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117509 NZ_CP035264:c1160516-1160274 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References