Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1651823..1652491 Replicon chromosome
Accession NZ_CP035263
Organism Streptococcus pneumoniae strain TVO_1901922

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag EQH17_RS08105 Protein ID WP_001132285.1
Coordinates 1652312..1652491 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH17_RS08100 Protein ID WP_000961810.1
Coordinates 1651823..1652275 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH17_RS08080 (EQH17_08565) 1648672..1649706 - 1035 WP_000747915.1 ATP-binding protein -
EQH17_RS08085 (EQH17_08570) 1649816..1649974 - 159 WP_000401986.1 7,8-dihydro-8-oxoguanine-triphosphatase -
EQH17_RS08090 (EQH17_08575) 1649976..1651043 - 1068 WP_000719723.1 site-2 protease family protein -
EQH17_RS08095 (EQH17_08580) 1651062..1651532 - 471 WP_000257084.1 DUF3013 family protein -
EQH17_RS08100 (EQH17_08585) 1651823..1652275 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH17_RS08105 (EQH17_08590) 1652312..1652491 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH17_RS08110 (EQH17_08595) 1652628..1652807 - 180 WP_001048906.1 hypothetical protein -
EQH17_RS08115 (EQH17_08605) 1652972..1653211 - 240 WP_000818078.1 hypothetical protein -
EQH17_RS08120 (EQH17_08615) 1653481..1654752 + 1272 WP_001113218.1 replication-associated recombination protein A -
EQH17_RS08130 (EQH17_08625) 1655299..1656618 - 1320 WP_000502558.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T117506 WP_001132285.1 NZ_CP035263:c1652491-1652312 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T117506 NZ_CP035263:c1652491-1652312 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117506 WP_000961810.1 NZ_CP035263:c1652275-1651823 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117506 NZ_CP035263:c1652275-1651823 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References