Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1657633..1658301 Replicon chromosome
Accession NZ_CP035262
Organism Streptococcus pneumoniae strain TVO_1901923

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQH18_RS08165 Protein ID WP_041170910.1
Coordinates 1658122..1658301 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH18_RS08160 Protein ID WP_000961810.1
Coordinates 1657633..1658085 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH18_RS08140 (EQH18_08605) 1654482..1655516 - 1035 WP_000747915.1 ATP-binding protein -
EQH18_RS08145 (EQH18_08610) 1655650..1655784 - 135 Protein_1624 7,8-dihydro-8-oxoguanine-triphosphatase -
EQH18_RS08150 (EQH18_08615) 1655765..1656853 - 1089 WP_000719722.1 site-2 protease family protein -
EQH18_RS08155 (EQH18_08620) 1656872..1657342 - 471 WP_000257097.1 DUF3013 family protein -
EQH18_RS08160 (EQH18_08625) 1657633..1658085 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH18_RS08165 (EQH18_08630) 1658122..1658301 - 180 WP_041170910.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH18_RS08170 (EQH18_08635) 1658438..1658617 - 180 WP_001809903.1 hypothetical protein -
EQH18_RS08175 (EQH18_08645) 1658782..1659003 - 222 WP_000425689.1 hypothetical protein -
EQH18_RS08180 (EQH18_08650) 1659295..1660566 + 1272 WP_001113178.1 replication-associated recombination protein A -
EQH18_RS08190 (EQH18_08660) 1661111..1662430 - 1320 WP_000502559.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6608.78 Da        Isoelectric Point: 10.8214

>T117502 WP_041170910.1 NZ_CP035262:c1658301-1658122 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHSELNKYTERGIGKQAGL

Download         Length: 180 bp

>T117502 NZ_CP035262:c1658301-1658122 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATAGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117502 WP_000961810.1 NZ_CP035262:c1658085-1657633 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117502 NZ_CP035262:c1658085-1657633 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References