Detailed information of TA system TA117502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1657633..1658301
• Replicon: chromosome
• Accession: NZ_CP035262
• Organism: Streptococcus pneumoniae strain TVO_1901923

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EQH18_RS08165
• Protein ID: WP_041170910.1
• Coordinates: 1658122..1658301 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: EQH18_RS08160
• Protein ID: WP_000961810.1
• Coordinates: 1657633..1658085 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH18_RS08140 (EQH18_08605)	1654482..1655516	-	1035	WP_000747915.1	ATP-binding protein	-
EQH18_RS08145 (EQH18_08610)	1655650..1655784	-	135	Protein_1624	7,8-dihydro-8-oxoguanine-triphosphatase	-
EQH18_RS08150 (EQH18_08615)	1655765..1656853	-	1089	WP_000719722.1	site-2 protease family protein	-
EQH18_RS08155 (EQH18_08620)	1656872..1657342	-	471	WP_000257097.1	DUF3013 family protein	-
EQH18_RS08160 (EQH18_08625)	1657633..1658085	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH18_RS08165 (EQH18_08630)	1658122..1658301	-	180	WP_041170910.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH18_RS08170 (EQH18_08635)	1658438..1658617	-	180	WP_001809903.1	hypothetical protein	-
EQH18_RS08175 (EQH18_08645)	1658782..1659003	-	222	WP_000425689.1	hypothetical protein	-
EQH18_RS08180 (EQH18_08650)	1659295..1660566	+	1272	WP_001113178.1	replication-associated recombination protein A	-
EQH18_RS08190 (EQH18_08660)	1661111..1662430	-	1320	WP_000502559.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6608.78 Da
• Isoelectric Point: 10.8214

>T117502 WP_041170910.1 NZ_CP035262:c1658301-1658122 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHSELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T117502 NZ_CP035262:c1658301-1658122 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATAGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT117502 WP_000961810.1 NZ_CP035262:c1658085-1657633 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117502 NZ_CP035262:c1658085-1657633 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: G0IC64