Detailed information of TA system TA117500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1029826..1030324
• Replicon: chromosome
• Accession: NZ_CP035262
• Organism: Streptococcus pneumoniae strain TVO_1901923

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQH18_RS05180
• Protein ID: WP_001812387.1
• Coordinates: 1030070..1030324 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EQH18_RS05175
• Protein ID: WP_000208080.1
• Coordinates: 1029826..1030068 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH18_RS05155 (EQH18_05445)	1025648..1026823	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
EQH18_RS05160 (EQH18_05450)	1026878..1027582	+	705	WP_000722076.1	response regulator YycF	-
EQH18_RS05165 (EQH18_05455)	1027575..1028924	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EQH18_RS05170 (EQH18_05460)	1028926..1029735	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EQH18_RS05175 (EQH18_05465)	1029826..1030068	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
EQH18_RS05180 (EQH18_05470)	1030070..1030324	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQH18_RS05185 (EQH18_05475)	1030371..1031023	+	653	Protein_1033	ion transporter	-
EQH18_RS05190 (EQH18_05480)	1031283..1032269	-	987	WP_000204727.1	L-lactate dehydrogenase	-
EQH18_RS05195 (EQH18_05485)	1032463..1034931	+	2469	WP_001152992.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T117500 WP_001812387.1 NZ_CP035262:1030070-1030324 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T117500 NZ_CP035262:1030070-1030324 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT117500 WP_000208080.1 NZ_CP035262:1029826-1030068 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT117500 NZ_CP035262:1029826-1030068 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7