Detailed information of TA system TA117498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1631441..1632109
• Replicon: chromosome
• Accession: NZ_CP035261
• Organism: Streptococcus pneumoniae strain TVO_1901924

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0B7M7X4
• Locus tag: EQH19_RS08205
• Protein ID: WP_001132284.1
• Coordinates: 1631930..1632109 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EQH19_RS08200
• Protein ID: WP_000961811.1
• Coordinates: 1631441..1631893 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH19_RS08175 (EQH19_08665)	1627333..1628076	-	744	WP_001188210.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
EQH19_RS08180 (EQH19_08670)	1628078..1629028	-	951	WP_000451152.1	50S ribosomal protein L11 methyltransferase	-
EQH19_RS08185 (EQH19_08675)	1629164..1629592	-	429	WP_000418174.1	NUDIX hydrolase	-
EQH19_RS08190 (EQH19_08680)	1629573..1630661	-	1089	WP_000719713.1	site-2 protease family protein	-
EQH19_RS08195 (EQH19_08685)	1630680..1631150	-	471	WP_000257086.1	DUF3013 family protein	-
EQH19_RS08200 (EQH19_08690)	1631441..1631893	-	453	WP_000961811.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH19_RS08205 (EQH19_08695)	1631930..1632109	-	180	WP_001132284.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH19_RS08210 (EQH19_08700)	1632246..1632425	-	180	WP_001048906.1	hypothetical protein	-
EQH19_RS08215 (EQH19_08710)	1632590..1632811	-	222	WP_000425689.1	hypothetical protein	-
EQH19_RS08220 (EQH19_08715)	1633103..1634374	+	1272	WP_001113212.1	replication-associated recombination protein A	-
EQH19_RS08230 (EQH19_08725)	1634919..1636238	-	1320	WP_000502556.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-115)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6713.95 Da
• Isoelectric Point: 11.0174

>T117498 WP_001132284.1 NZ_CP035261:c1632109-1631930 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Nucleotide

• Length: 180 bp

>T117498 NZ_CP035261:c1632109-1631930 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16649.42 Da
• Isoelectric Point: 3.7220

>AT117498 WP_000961811.1 NZ_CP035261:c1631893-1631441 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTISKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117498 NZ_CP035261:c1631893-1631441 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATATCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGGCTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0B7M7X4