117496

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1152603..1153101 Replicon chromosome
Accession NZ_CP035261
Organism Streptococcus pneumoniae strain TVO_1901924

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH19_RS05725 Protein ID WP_001809704.1
Coordinates 1152603..1152857 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH19_RS05730 Protein ID WP_000208080.1
Coordinates 1152859..1153101 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH19_RS05710 (EQH19_06075) 1147887..1150355 - 2469 WP_001152992.1 DNA gyrase subunit A -
EQH19_RS05715 (EQH19_06080) 1150549..1151535 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH19_RS05720 (EQH19_06085) 1151783..1152556 - 774 WP_000731139.1 ion channel -
EQH19_RS05725 (EQH19_06090) 1152603..1152857 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH19_RS05730 (EQH19_06095) 1152859..1153101 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH19_RS05735 (EQH19_06100) 1153192..1154001 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH19_RS05740 (EQH19_06105) 1154003..1155352 - 1350 WP_001861620.1 cell wall metabolism sensor histidine kinase VicK -
EQH19_RS05745 (EQH19_06110) 1155345..1156049 - 705 WP_000722076.1 response regulator YycF -
EQH19_RS05750 (EQH19_06115) 1156104..1157279 - 1176 WP_000886153.1 A/G-specific adenine glycosylase -
EQH19_RS10775 1157376..1157501 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117496 WP_001809704.1 NZ_CP035261:c1152857-1152603 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117496 NZ_CP035261:c1152857-1152603 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATTGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117496 WP_000208080.1 NZ_CP035261:c1153101-1152859 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117496 NZ_CP035261:c1153101-1152859 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References