117482

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1722503..1723171 Replicon chromosome
Accession NZ_CP035256
Organism Streptococcus pneumoniae strain TVO_1901930

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQH24_RS08805 Protein ID WP_023396413.1
Coordinates 1722992..1723171 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EQH24_RS08800 Protein ID WP_023396412.1
Coordinates 1722503..1722955 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH24_RS08770 (EQH24_09210) 1718357..1719100 - 744 WP_023396408.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EQH24_RS08775 (EQH24_09215) 1719102..1720052 - 951 WP_023396409.1 50S ribosomal protein L11 methyltransferase -
EQH24_RS08780 (EQH24_09220) 1720190..1720663 - 474 WP_023396410.1 GNAT family N-acetyltransferase -
EQH24_RS08785 (EQH24_09225) 1720660..1721094 - 435 WP_000421871.1 NUDIX hydrolase -
EQH24_RS08790 (EQH24_09230) 1721144..1721686 - 543 WP_000891117.1 hypothetical protein -
EQH24_RS08795 (EQH24_09235) 1721742..1722212 - 471 WP_023396411.1 DUF3013 family protein -
EQH24_RS08800 (EQH24_09240) 1722503..1722955 - 453 WP_023396412.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH24_RS08805 (EQH24_09245) 1722992..1723171 - 180 WP_023396413.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH24_RS08810 (EQH24_09250) 1723308..1723487 - 180 WP_001048906.1 hypothetical protein -
EQH24_RS08815 (EQH24_09260) 1723652..1723891 - 240 WP_000818078.1 hypothetical protein -
EQH24_RS08820 (EQH24_09270) 1724161..1725432 + 1272 WP_023396414.1 replication-associated recombination protein A -
EQH24_RS08830 (EQH24_09280) 1725977..1727296 - 1320 WP_000502550.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6742.00 Da        Isoelectric Point: 11.0174

>T117482 WP_023396413.1 NZ_CP035256:c1723171-1722992 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQVGL

Download         Length: 180 bp

>T117482 NZ_CP035256:c1723171-1722992 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGTTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16645.43 Da        Isoelectric Point: 3.7154

>AT117482 WP_023396412.1 NZ_CP035256:c1722955-1722503 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISDALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117482 NZ_CP035256:c1722955-1722503 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGATGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References