Detailed information of TA system TA117481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1195886..1196384
• Replicon: chromosome
• Accession: NZ_CP035256
• Organism: Streptococcus pneumoniae strain TVO_1901930

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQH24_RS06060
• Protein ID: WP_023396660.1
• Coordinates: 1195886..1196140 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EQH24_RS06065
• Protein ID: WP_000208080.1
• Coordinates: 1196142..1196384 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH24_RS06045 (EQH24_06365)	1191159..1193627	-	2469	WP_001152989.1	DNA gyrase subunit A	-
EQH24_RS06050 (EQH24_06370)	1193821..1194807	+	987	WP_000204727.1	L-lactate dehydrogenase	-
EQH24_RS06055 (EQH24_06375)	1195063..1195839	-	777	WP_023396659.1	ion channel	-
EQH24_RS06060 (EQH24_06380)	1195886..1196140	-	255	WP_023396660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQH24_RS06065 (EQH24_06385)	1196142..1196384	-	243	WP_000208080.1	DUF6290 family protein	Antitoxin
EQH24_RS06070 (EQH24_06390)	1196475..1197284	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EQH24_RS06075 (EQH24_06395)	1197286..1198635	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EQH24_RS06080 (EQH24_06400)	1198628..1199332	-	705	WP_000722076.1	response regulator YycF	-
EQH24_RS06085 (EQH24_06405)	1199387..1200562	-	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
EQH24_RS11650	1200659..1200784	+	126	WP_001818232.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10112.82 Da
• Isoelectric Point: 10.7632

>T117481 WP_023396660.1 NZ_CP035256:c1196140-1195886 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALIGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T117481 NZ_CP035256:c1196140-1195886 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGATTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT117481 WP_000208080.1 NZ_CP035256:c1196384-1196142 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT117481 NZ_CP035256:c1196384-1196142 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7