Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1670159..1670827 Replicon chromosome
Accession NZ_CP035252
Organism Streptococcus pneumoniae strain TVO_1901934

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQH28_RS08355 Protein ID WP_025169096.1
Coordinates 1670648..1670827 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH28_RS08350 Protein ID WP_000961810.1
Coordinates 1670159..1670611 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH28_RS08325 (EQH28_08830) 1666049..1666792 - 744 WP_001188207.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EQH28_RS08330 (EQH28_08835) 1666794..1667744 - 951 WP_000451134.1 50S ribosomal protein L11 methyltransferase -
EQH28_RS08335 (EQH28_08840) 1667882..1668310 - 429 WP_000401988.1 NUDIX hydrolase -
EQH28_RS08340 (EQH28_08845) 1668312..1669379 - 1068 WP_000719721.1 site-2 protease family protein -
EQH28_RS08345 (EQH28_08850) 1669398..1669868 - 471 WP_000257084.1 DUF3013 family protein -
EQH28_RS08350 (EQH28_08855) 1670159..1670611 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH28_RS08355 (EQH28_08860) 1670648..1670827 - 180 WP_025169096.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH28_RS08360 (EQH28_08865) 1670964..1671143 - 180 WP_001809903.1 hypothetical protein -
EQH28_RS08365 (EQH28_08875) 1671308..1671546 - 239 Protein_1667 hypothetical protein -
EQH28_RS08370 (EQH28_08885) 1671816..1673087 + 1272 WP_001113208.1 replication-associated recombination protein A -
EQH28_RS08380 (EQH28_08895) 1673633..1674952 - 1320 WP_000502548.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6578.75 Da        Isoelectric Point: 10.8214

>T117476 WP_025169096.1 NZ_CP035252:c1670827-1670648 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 180 bp

>T117476 NZ_CP035252:c1670827-1670648 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117476 WP_000961810.1 NZ_CP035252:c1670611-1670159 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117476 NZ_CP035252:c1670611-1670159 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References