Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1112712..1113210 Replicon chromosome
Accession NZ_CP035252
Organism Streptococcus pneumoniae strain TVO_1901934

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQH28_RS05530 Protein ID WP_001823540.1
Coordinates 1112712..1112966 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH28_RS05535 Protein ID WP_000208080.1
Coordinates 1112968..1113210 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH28_RS05515 (EQH28_05860) 1107973..1110441 - 2469 WP_001152990.1 DNA gyrase subunit A -
EQH28_RS05520 (EQH28_05865) 1110635..1111621 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH28_RS05525 (EQH28_05870) 1111970..1112665 - 696 WP_000731163.1 potassium channel family protein -
EQH28_RS05530 (EQH28_05875) 1112712..1112966 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH28_RS05535 (EQH28_05880) 1112968..1113210 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH28_RS05540 (EQH28_05885) 1113301..1114110 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH28_RS05545 (EQH28_05890) 1114112..1115461 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH28_RS05550 (EQH28_05895) 1115454..1116158 - 705 WP_000722076.1 response regulator YycF -
EQH28_RS05555 (EQH28_05900) 1116214..1117389 - 1176 WP_000886152.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T117475 WP_001823540.1 NZ_CP035252:c1112966-1112712 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117475 NZ_CP035252:c1112966-1112712 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117475 WP_000208080.1 NZ_CP035252:c1113210-1112968 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117475 NZ_CP035252:c1113210-1112968 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References