Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 956987..958224 Replicon chromosome
Accession NZ_CP035252
Organism Streptococcus pneumoniae strain TVO_1901934

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag EQH28_RS04830 Protein ID WP_000405365.1
Coordinates 957463..958224 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag EQH28_RS04825 Protein ID WP_000579599.1
Coordinates 956987..957463 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH28_RS04805 (EQH28_05135) 952050..952904 + 855 WP_000900017.1 ADP-ribosylglycohydrolase family protein -
EQH28_RS04810 (EQH28_05140) 953016..953900 + 885 WP_000710115.1 diacylglycerol kinase family lipid kinase -
EQH28_RS04815 (EQH28_05145) 954063..955802 + 1740 WP_000423466.1 glycoside hydrolase family 13 protein -
EQH28_RS04820 (EQH28_05150) 956077..956397 + 321 WP_061751326.1 hypothetical protein -
EQH28_RS04825 (EQH28_05155) 956987..957463 + 477 WP_000579599.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
EQH28_RS04830 (EQH28_05160) 957463..958224 + 762 WP_000405365.1 type II toxin-antitoxin system toxin PezT Toxin
EQH28_RS04835 (EQH28_05165) 958252..959028 + 777 WP_001821017.1 hypothetical protein -
EQH28_RS04840 959031..959408 + 378 WP_000530000.1 hypothetical protein -
EQH28_RS04845 (EQH28_05175) 960227..960586 + 360 WP_000003745.1 SAG1252 family conjugative relaxosome accessory protein -
EQH28_RS04850 (EQH28_05180) 960596..960961 + 366 WP_000263051.1 plasmid mobilization relaxosome protein MobC -
EQH28_RS04855 (EQH28_05185) 960948..962813 + 1866 WP_000261794.1 SAG1250 family conjugative relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 945564..958224 12660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29060.05 Da        Isoelectric Point: 6.8511

>T117474 WP_000405365.1 NZ_CP035252:957463-958224 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T117474 NZ_CP035252:957463-958224 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATCGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGCATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18251.60 Da        Isoelectric Point: 4.3571

>AT117474 WP_000579599.1 NZ_CP035252:956987-957463 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT117474 NZ_CP035252:956987-957463 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAAGACGACTTTTCCCGAATTGTAGGAATTTC
TCGAAATAGCTTGAGCCGGTATGAAAATGGAACTAGTTCAGTCTCTACGGAACTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References