Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1641934..1642602 Replicon chromosome
Accession NZ_CP035251
Organism Streptococcus pneumoniae strain TVO_1901935

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQH29_RS08095 Protein ID WP_025169096.1
Coordinates 1642423..1642602 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH29_RS08090 Protein ID WP_000961810.1
Coordinates 1641934..1642386 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH29_RS08065 (EQH29_08575) 1637824..1638567 - 744 WP_001188207.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EQH29_RS08070 (EQH29_08580) 1638569..1639519 - 951 WP_000451134.1 50S ribosomal protein L11 methyltransferase -
EQH29_RS08075 (EQH29_08585) 1639657..1640085 - 429 WP_000401988.1 NUDIX hydrolase -
EQH29_RS08080 (EQH29_08590) 1640087..1641154 - 1068 WP_000719721.1 site-2 protease family protein -
EQH29_RS08085 (EQH29_08595) 1641173..1641643 - 471 WP_000257084.1 DUF3013 family protein -
EQH29_RS08090 (EQH29_08600) 1641934..1642386 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH29_RS08095 (EQH29_08605) 1642423..1642602 - 180 WP_025169096.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH29_RS08100 (EQH29_08610) 1642739..1642918 - 180 WP_001809903.1 hypothetical protein -
EQH29_RS08105 (EQH29_08620) 1643083..1643321 - 239 Protein_1614 hypothetical protein -
EQH29_RS08110 (EQH29_08630) 1643591..1644862 + 1272 WP_001113208.1 replication-associated recombination protein A -
EQH29_RS08120 (EQH29_08640) 1645408..1646727 - 1320 WP_000502548.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6578.75 Da        Isoelectric Point: 10.8214

>T117473 WP_025169096.1 NZ_CP035251:c1642602-1642423 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 180 bp

>T117473 NZ_CP035251:c1642602-1642423 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117473 WP_000961810.1 NZ_CP035251:c1642386-1641934 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117473 NZ_CP035251:c1642386-1641934 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References