Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1156263..1156761 Replicon chromosome
Accession NZ_CP035249
Organism Streptococcus pneumoniae strain TVO_1901938

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH31_RS05890 Protein ID WP_001809704.1
Coordinates 1156263..1156517 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH31_RS05895 Protein ID WP_000208080.1
Coordinates 1156519..1156761 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH31_RS05875 (EQH31_06240) 1151535..1154003 - 2469 WP_001152988.1 DNA gyrase subunit A -
EQH31_RS05880 (EQH31_06245) 1154197..1155183 + 987 WP_000204724.1 L-lactate dehydrogenase -
EQH31_RS05885 (EQH31_06250) 1155443..1156216 - 774 WP_000731131.1 ion channel -
EQH31_RS05890 (EQH31_06255) 1156263..1156517 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH31_RS05895 (EQH31_06260) 1156519..1156761 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH31_RS05900 (EQH31_06265) 1156852..1157661 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH31_RS05905 (EQH31_06270) 1157663..1159012 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH31_RS05910 (EQH31_06275) 1159005..1159709 - 705 WP_000722076.1 response regulator YycF -
EQH31_RS05915 (EQH31_06280) 1159764..1160939 - 1176 WP_000886148.1 A/G-specific adenine glycosylase -
EQH31_RS11075 1161036..1161161 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117469 WP_001809704.1 NZ_CP035249:c1156517-1156263 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117469 NZ_CP035249:c1156517-1156263 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117469 WP_000208080.1 NZ_CP035249:c1156761-1156519 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117469 NZ_CP035249:c1156761-1156519 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References