Detailed information of TA system TA117468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1613250..1613918
• Replicon: chromosome
• Accession: NZ_CP035248
• Organism: Streptococcus pneumoniae strain TVO_1901939

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EQH32_RS08195
• Protein ID: WP_025169096.1
• Coordinates: 1613739..1613918 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: EQH32_RS08190
• Protein ID: WP_000961810.1
• Coordinates: 1613250..1613702 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH32_RS08170 (EQH32_08590)	1610099..1611133	-	1035	WP_000747915.1	ATP-binding protein	-
EQH32_RS08175 (EQH32_08595)	1611267..1611401	-	135	Protein_1631	7,8-dihydro-8-oxoguanine-triphosphatase	-
EQH32_RS08180 (EQH32_08600)	1611382..1612470	-	1089	WP_000719726.1	site-2 protease family protein	-
EQH32_RS08185 (EQH32_08605)	1612489..1612959	-	471	WP_000257085.1	DUF3013 family protein	-
EQH32_RS08190 (EQH32_08610)	1613250..1613702	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH32_RS08195 (EQH32_08615)	1613739..1613918	-	180	WP_025169096.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH32_RS08200 (EQH32_08620)	1614055..1614234	-	180	WP_001809903.1	hypothetical protein	-
EQH32_RS08205 (EQH32_08630)	1614399..1614617	-	219	WP_001273377.1	hypothetical protein	-
EQH32_RS08210 (EQH32_08635)	1614610..1615563	-	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
EQH32_RS08215 (EQH32_08640)	1616154..1617425	+	1272	WP_001113209.1	replication-associated recombination protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1614610..1615563	953

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6578.75 Da
• Isoelectric Point: 10.8214

>T117468 WP_025169096.1 NZ_CP035248:c1613918-1613739 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T117468 NZ_CP035248:c1613918-1613739 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT117468 WP_000961810.1 NZ_CP035248:c1613702-1613250 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117468 NZ_CP035248:c1613702-1613250 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• PDB: 5YRZ
• AlphaFold DB: G0IC64