Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1132622..1133120 | Replicon | chromosome |
Accession | NZ_CP035248 | ||
Organism | Streptococcus pneumoniae strain TVO_1901939 |
Toxin (Protein)
Gene name | relE | Uniprot ID | B1IC19 |
Locus tag | EQH32_RS05745 | Protein ID | WP_001809704.1 |
Coordinates | 1132622..1132876 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | B1IC20 |
Locus tag | EQH32_RS05750 | Protein ID | WP_000208080.1 |
Coordinates | 1132878..1133120 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQH32_RS05730 (EQH32_06020) | 1127894..1130362 | - | 2469 | WP_001152988.1 | DNA gyrase subunit A | - |
EQH32_RS05735 (EQH32_06025) | 1130556..1131542 | + | 987 | WP_000204724.1 | L-lactate dehydrogenase | - |
EQH32_RS05740 (EQH32_06030) | 1131802..1132575 | - | 774 | WP_000731131.1 | ion channel | - |
EQH32_RS05745 (EQH32_06035) | 1132622..1132876 | - | 255 | WP_001809704.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EQH32_RS05750 (EQH32_06040) | 1132878..1133120 | - | 243 | WP_000208080.1 | DUF6290 family protein | Antitoxin |
EQH32_RS05755 (EQH32_06045) | 1133211..1134020 | - | 810 | WP_001289493.1 | MBL fold metallo-hydrolase | - |
EQH32_RS05760 (EQH32_06050) | 1134022..1135371 | - | 1350 | WP_000886210.1 | cell wall metabolism sensor histidine kinase VicK | - |
EQH32_RS05765 (EQH32_06055) | 1135364..1136068 | - | 705 | WP_000722076.1 | response regulator YycF | - |
EQH32_RS05770 (EQH32_06060) | 1136123..1137298 | - | 1176 | WP_000886148.1 | A/G-specific adenine glycosylase | - |
EQH32_RS10760 | 1137395..1137520 | + | 126 | WP_001818232.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10098.79 Da Isoelectric Point: 10.7632
>T117467 WP_001809704.1 NZ_CP035248:c1132876-1132622 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
Download Length: 255 bp
>T117467 NZ_CP035248:c1132876-1132622 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9205.46 Da Isoelectric Point: 4.0527
>AT117467 WP_000208080.1 NZ_CP035248:c1133120-1132878 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
Download Length: 243 bp
>AT117467 NZ_CP035248:c1133120-1132878 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A853PEW4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A064C2J7 |