Detailed information of TA system TA117466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1585581..1586249
• Replicon: chromosome
• Accession: NZ_CP035247
• Organism: Streptococcus pneumoniae strain TVO_1901940

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EQH33_RS07905
• Protein ID: WP_001132283.1
• Coordinates: 1586070..1586249 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EQH33_RS07900
• Protein ID: WP_000961814.1
• Coordinates: 1585581..1586033 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH33_RS07875 (EQH33_08355)	1581471..1582214	-	744	WP_001188206.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
EQH33_RS07880 (EQH33_08360)	1582216..1583169	-	954	WP_000970782.1	50S ribosomal protein L11 methyltransferase	-
EQH33_RS07885 (EQH33_08365)	1583304..1583732	-	429	WP_000418170.1	NUDIX hydrolase	-
EQH33_RS07890 (EQH33_08370)	1583713..1584801	-	1089	WP_000719722.1	site-2 protease family protein	-
EQH33_RS07895 (EQH33_08375)	1584820..1585290	-	471	WP_000257097.1	DUF3013 family protein	-
EQH33_RS07900 (EQH33_08380)	1585581..1586033	-	453	WP_000961814.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH33_RS07905 (EQH33_08385)	1586070..1586249	-	180	WP_001132283.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH33_RS07910 (EQH33_08390)	1586386..1586565	-	180	WP_001048906.1	hypothetical protein	-
EQH33_RS07915 (EQH33_08400)	1586730..1586951	-	222	WP_000425689.1	hypothetical protein	-
EQH33_RS07920 (EQH33_08405)	1587243..1588514	+	1272	WP_001113184.1	replication-associated recombination protein A	-
EQH33_RS07930 (EQH33_08415)	1589059..1590378	-	1320	WP_000608888.1	glycoside hydrolase family 32 protein	-
EQH33_RS07935 (EQH33_08420)	1590388..1591233	-	846	WP_000819519.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6614.82 Da
• Isoelectric Point: 10.8214

>T117466 WP_001132283.1 NZ_CP035247:c1586249-1586070 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T117466 NZ_CP035247:c1586249-1586070 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16647.40 Da
• Isoelectric Point: 3.7220

>AT117466 WP_000961814.1 NZ_CP035247:c1586033-1585581 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGTSEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117466 NZ_CP035247:c1586033-1585581 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGACTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA