Detailed information of TA system TA117464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 944509..945007
• Replicon: chromosome
• Accession: NZ_CP035247
• Organism: Streptococcus pneumoniae strain TVO_1901940

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQH33_RS04755
• Protein ID: WP_001812387.1
• Coordinates: 944753..945007 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EQH33_RS04750
• Protein ID: WP_000208080.1
• Coordinates: 944509..944751 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH33_RS04730 (EQH33_05055)	940331..941506	+	1176	WP_000886144.1	A/G-specific adenine glycosylase	-
EQH33_RS04735 (EQH33_05060)	941561..942265	+	705	WP_000722076.1	response regulator YycF	-
EQH33_RS04740 (EQH33_05065)	942258..943607	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EQH33_RS04745 (EQH33_05070)	943609..944418	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EQH33_RS04750 (EQH33_05075)	944509..944751	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
EQH33_RS04755 (EQH33_05080)	944753..945007	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQH33_RS04760 (EQH33_05085)	945054..945797	+	744	WP_000731133.1	potassium channel family protein	-
EQH33_RS04765 (EQH33_05090)	946086..947072	-	987	WP_000204731.1	L-lactate dehydrogenase	-
EQH33_RS04770 (EQH33_05095)	947266..949734	+	2469	WP_001152994.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T117464 WP_001812387.1 NZ_CP035247:944753-945007 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T117464 NZ_CP035247:944753-945007 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT117464 WP_000208080.1 NZ_CP035247:944509-944751 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT117464 NZ_CP035247:944509-944751 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7