Detailed information of TA system TA117463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1585632..1586300
• Replicon: chromosome
• Accession: NZ_CP035246
• Organism: Streptococcus pneumoniae strain TVO_1901941

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EQH34_RS07900
• Protein ID: WP_001132283.1
• Coordinates: 1586121..1586300 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EQH34_RS07895
• Protein ID: WP_000961814.1
• Coordinates: 1585632..1586084 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH34_RS07870 (EQH34_08350)	1581522..1582265	-	744	WP_001188206.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
EQH34_RS07875 (EQH34_08355)	1582267..1583220	-	954	WP_000970782.1	50S ribosomal protein L11 methyltransferase	-
EQH34_RS07880 (EQH34_08360)	1583355..1583783	-	429	WP_000418170.1	NUDIX hydrolase	-
EQH34_RS07885 (EQH34_08365)	1583764..1584852	-	1089	WP_000719722.1	site-2 protease family protein	-
EQH34_RS07890 (EQH34_08370)	1584871..1585341	-	471	WP_000257097.1	DUF3013 family protein	-
EQH34_RS07895 (EQH34_08375)	1585632..1586084	-	453	WP_000961814.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH34_RS07900 (EQH34_08380)	1586121..1586300	-	180	WP_001132283.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH34_RS07905 (EQH34_08385)	1586437..1586616	-	180	WP_001048906.1	hypothetical protein	-
EQH34_RS07910 (EQH34_08395)	1586781..1587002	-	222	WP_000425689.1	hypothetical protein	-
EQH34_RS07915 (EQH34_08400)	1587294..1588565	+	1272	WP_001113184.1	replication-associated recombination protein A	-
EQH34_RS07925 (EQH34_08410)	1589110..1590429	-	1320	WP_000608888.1	glycoside hydrolase family 32 protein	-
EQH34_RS07930 (EQH34_08415)	1590439..1591284	-	846	WP_000819519.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6614.82 Da
• Isoelectric Point: 10.8214

>T117463 WP_001132283.1 NZ_CP035246:c1586300-1586121 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T117463 NZ_CP035246:c1586300-1586121 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16647.40 Da
• Isoelectric Point: 3.7220

>AT117463 WP_000961814.1 NZ_CP035246:c1586084-1585632 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGTSEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117463 NZ_CP035246:c1586084-1585632 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGACTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA