Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 862718..863216 | Replicon | chromosome |
Accession | NZ_CP035246 | ||
Organism | Streptococcus pneumoniae strain TVO_1901941 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | EQH34_RS04285 | Protein ID | WP_001812387.1 |
Coordinates | 862718..862972 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | B1IC20 |
Locus tag | EQH34_RS04290 | Protein ID | WP_000208080.1 |
Coordinates | 862974..863216 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQH34_RS04270 (EQH34_04560) | 857991..860459 | - | 2469 | WP_001152994.1 | DNA gyrase subunit A | - |
EQH34_RS04275 (EQH34_04565) | 860653..861639 | + | 987 | WP_000204731.1 | L-lactate dehydrogenase | - |
EQH34_RS04280 (EQH34_04570) | 861928..862671 | - | 744 | WP_000731133.1 | potassium channel family protein | - |
EQH34_RS04285 (EQH34_04575) | 862718..862972 | - | 255 | WP_001812387.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EQH34_RS04290 (EQH34_04580) | 862974..863216 | - | 243 | WP_000208080.1 | DUF6290 family protein | Antitoxin |
EQH34_RS04295 (EQH34_04585) | 863307..864116 | - | 810 | WP_001289493.1 | MBL fold metallo-hydrolase | - |
EQH34_RS04300 (EQH34_04590) | 864118..865467 | - | 1350 | WP_000886210.1 | cell wall metabolism sensor histidine kinase VicK | - |
EQH34_RS04305 (EQH34_04595) | 865460..866164 | - | 705 | WP_000722076.1 | response regulator YycF | - |
EQH34_RS04310 (EQH34_04600) | 866219..867394 | - | 1176 | WP_000886144.1 | A/G-specific adenine glycosylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10110.85 Da Isoelectric Point: 10.7632
>T117461 WP_001812387.1 NZ_CP035246:c862972-862718 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
Download Length: 255 bp
>T117461 NZ_CP035246:c862972-862718 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9205.46 Da Isoelectric Point: 4.0527
>AT117461 WP_000208080.1 NZ_CP035246:c863216-862974 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
Download Length: 243 bp
>AT117461 NZ_CP035246:c863216-862974 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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