117461

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 862718..863216 Replicon chromosome
Accession NZ_CP035246
Organism Streptococcus pneumoniae strain TVO_1901941

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EQH34_RS04285 Protein ID WP_001812387.1
Coordinates 862718..862972 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH34_RS04290 Protein ID WP_000208080.1
Coordinates 862974..863216 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH34_RS04270 (EQH34_04560) 857991..860459 - 2469 WP_001152994.1 DNA gyrase subunit A -
EQH34_RS04275 (EQH34_04565) 860653..861639 + 987 WP_000204731.1 L-lactate dehydrogenase -
EQH34_RS04280 (EQH34_04570) 861928..862671 - 744 WP_000731133.1 potassium channel family protein -
EQH34_RS04285 (EQH34_04575) 862718..862972 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH34_RS04290 (EQH34_04580) 862974..863216 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH34_RS04295 (EQH34_04585) 863307..864116 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH34_RS04300 (EQH34_04590) 864118..865467 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH34_RS04305 (EQH34_04595) 865460..866164 - 705 WP_000722076.1 response regulator YycF -
EQH34_RS04310 (EQH34_04600) 866219..867394 - 1176 WP_000886144.1 A/G-specific adenine glycosylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T117461 WP_001812387.1 NZ_CP035246:c862972-862718 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117461 NZ_CP035246:c862972-862718 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117461 WP_000208080.1 NZ_CP035246:c863216-862974 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117461 NZ_CP035246:c863216-862974 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References