Detailed information of TA system TA117459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1119518..1120016
• Replicon: chromosome
• Accession: NZ_CP035245
• Organism: Streptococcus pneumoniae strain TVO_1901943

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EQH35_RS05700
• Protein ID: WP_001812387.1
• Coordinates: 1119518..1119772 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: EQH35_RS05705
• Protein ID: WP_000208080.1
• Coordinates: 1119774..1120016 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH35_RS05685 (EQH35_06005)	1114778..1117246	-	2469	WP_001152997.1	DNA gyrase subunit A	-
EQH35_RS05690 (EQH35_06010)	1117440..1118426	+	987	WP_000204733.1	L-lactate dehydrogenase	-
EQH35_RS05695 (EQH35_06015)	1118775..1119428	-	654	WP_238125047.1	potassium channel family protein	-
EQH35_RS05700 (EQH35_06020)	1119518..1119772	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQH35_RS05705 (EQH35_06025)	1119774..1120016	-	243	WP_000208080.1	DUF6290 family protein	Antitoxin
EQH35_RS05710 (EQH35_06030)	1120107..1120916	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
EQH35_RS05715 (EQH35_06035)	1120918..1122267	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
EQH35_RS05720 (EQH35_06040)	1122260..1122964	-	705	WP_000722076.1	response regulator YycF	-
EQH35_RS05725 (EQH35_06045)	1123019..1124194	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T117459 WP_001812387.1 NZ_CP035245:c1119772-1119518 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T117459 NZ_CP035245:c1119772-1119518 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT117459 WP_000208080.1 NZ_CP035245:c1120016-1119774 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT117459 NZ_CP035245:c1120016-1119774 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7