Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1621993..1622661 Replicon chromosome
Accession NZ_CP035244
Organism Streptococcus pneumoniae strain TVO_1901945

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag EQH36_RS08185 Protein ID WP_001132282.1
Coordinates 1622482..1622661 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH36_RS08180 Protein ID WP_000961810.1
Coordinates 1621993..1622445 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH36_RS08155 (EQH36_08580) 1617031..1619274 - 2244 WP_001094321.1 S8 family serine peptidase -
EQH36_RS08160 (EQH36_08585) 1619276..1620310 - 1035 WP_000747915.1 ATP-binding protein -
EQH36_RS08165 (EQH36_08590) 1620420..1620584 - 165 WP_000421870.1 hypothetical protein -
EQH36_RS08170 (EQH36_08595) 1620634..1621176 - 543 WP_000891119.1 hypothetical protein -
EQH36_RS08175 (EQH36_08600) 1621232..1621702 - 471 WP_000257102.1 DUF3013 family protein -
EQH36_RS08180 (EQH36_08605) 1621993..1622445 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH36_RS08185 (EQH36_08610) 1622482..1622661 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH36_RS08190 (EQH36_08615) 1622798..1622977 - 180 WP_001048906.1 hypothetical protein -
EQH36_RS08195 (EQH36_08625) 1623181..1623381 - 201 WP_000818077.1 hypothetical protein -
EQH36_RS08200 (EQH36_08635) 1623651..1624922 + 1272 WP_001113214.1 replication-associated recombination protein A -
EQH36_RS08210 (EQH36_08645) 1625469..1626788 - 1320 WP_000502537.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T117457 WP_001132282.1 NZ_CP035244:c1622661-1622482 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117457 NZ_CP035244:c1622661-1622482 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117457 WP_000961810.1 NZ_CP035244:c1622445-1621993 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117457 NZ_CP035244:c1622445-1621993 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References