Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1147568..1148066 Replicon chromosome
Accession NZ_CP035244
Organism Streptococcus pneumoniae strain TVO_1901945

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQH36_RS05745 Protein ID WP_001823540.1
Coordinates 1147568..1147822 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH36_RS05750 Protein ID WP_000208080.1
Coordinates 1147824..1148066 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH36_RS05730 (EQH36_06035) 1142829..1145297 - 2469 WP_001152992.1 DNA gyrase subunit A -
EQH36_RS05735 (EQH36_06040) 1145491..1146477 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH36_RS05740 (EQH36_06045) 1146826..1147521 - 696 WP_000731163.1 potassium channel family protein -
EQH36_RS05745 (EQH36_06050) 1147568..1147822 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH36_RS05750 (EQH36_06055) 1147824..1148066 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH36_RS05755 (EQH36_06060) 1148157..1148966 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH36_RS05760 (EQH36_06065) 1148968..1150317 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH36_RS05765 (EQH36_06070) 1150310..1151014 - 705 WP_000722076.1 response regulator YycF -
EQH36_RS05770 (EQH36_06075) 1151069..1152244 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
EQH36_RS10850 1152341..1152466 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T117456 WP_001823540.1 NZ_CP035244:c1147822-1147568 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117456 NZ_CP035244:c1147822-1147568 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117456 WP_000208080.1 NZ_CP035244:c1148066-1147824 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117456 NZ_CP035244:c1148066-1147824 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References