Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1691712..1692380 Replicon chromosome
Accession NZ_CP035243
Organism Streptococcus pneumoniae strain TVO_1901946

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQH37_RS08355 Protein ID WP_000930275.1
Coordinates 1692201..1692380 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH37_RS08350 Protein ID WP_000961810.1
Coordinates 1691712..1692164 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH37_RS08325 (EQH37_08815) 1687602..1688345 - 744 WP_001188198.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EQH37_RS08330 (EQH37_08820) 1688347..1689300 - 954 WP_000970783.1 50S ribosomal protein L11 methyltransferase -
EQH37_RS08335 (EQH37_08825) 1689435..1689863 - 429 WP_000402002.1 NUDIX hydrolase -
EQH37_RS08340 (EQH37_08830) 1689865..1690932 - 1068 WP_000719708.1 site-2 protease family protein -
EQH37_RS08345 (EQH37_08835) 1690951..1691421 - 471 WP_000257104.1 DUF3013 family protein -
EQH37_RS08350 (EQH37_08840) 1691712..1692164 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH37_RS08355 (EQH37_08845) 1692201..1692380 - 180 WP_000930275.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH37_RS08360 (EQH37_08850) 1692517..1692696 - 180 WP_001048906.1 hypothetical protein -
EQH37_RS08365 (EQH37_08860) 1692861..1693100 - 240 WP_000818078.1 hypothetical protein -
EQH37_RS08370 (EQH37_08870) 1693370..1694641 + 1272 WP_001113216.1 replication-associated recombination protein A -
EQH37_RS08380 (EQH37_08880) 1695185..1696504 - 1320 WP_054362602.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6729.99 Da        Isoelectric Point: 11.0174

>T117454 WP_000930275.1 NZ_CP035243:c1692380-1692201 [Streptococcus pneumoniae]
MLMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117454 NZ_CP035243:c1692380-1692201 [Streptococcus pneumoniae]
ATGCTTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117454 WP_000961810.1 NZ_CP035243:c1692164-1691712 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117454 NZ_CP035243:c1692164-1691712 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References