Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1166369..1166867 Replicon chromosome
Accession NZ_CP035243
Organism Streptococcus pneumoniae strain TVO_1901946

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH37_RS05790 Protein ID WP_001809704.1
Coordinates 1166369..1166623 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH37_RS05795 Protein ID WP_000208080.1
Coordinates 1166625..1166867 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH37_RS05785 (EQH37_06115) 1164423..1166294 - 1872 WP_000150982.1 Eco57I restriction-modification methylase domain-containing protein -
EQH37_RS05790 (EQH37_06120) 1166369..1166623 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH37_RS05795 (EQH37_06125) 1166625..1166867 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH37_RS05800 (EQH37_06130) 1166958..1167767 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH37_RS05805 (EQH37_06135) 1167769..1169118 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH37_RS05810 (EQH37_06140) 1169111..1169815 - 705 WP_000722076.1 response regulator YycF -
EQH37_RS05815 (EQH37_06145) 1169870..1171045 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -
EQH37_RS10875 1171142..1171267 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117453 WP_001809704.1 NZ_CP035243:c1166623-1166369 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117453 NZ_CP035243:c1166623-1166369 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117453 WP_000208080.1 NZ_CP035243:c1166867-1166625 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117453 NZ_CP035243:c1166867-1166625 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References