Detailed information of TA system TA117451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1314264..1315516
• Replicon: chromosome
• Accession: NZ_CP035242
• Organism: Streptococcus pneumoniae strain TVO_1901947

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: EQH38_RS06780
• Protein ID: WP_054365402.1
• Coordinates: 1314264..1315040 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: B6ZCC4
• Locus tag: EQH38_RS06785
• Protein ID: WP_000579612.1
• Coordinates: 1315040..1315516 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH38_RS06760 (EQH38_07130)	1309366..1309731	-	366	WP_000431637.1	MobC family plasmid mobilization relaxosome protein	-
EQH38_RS06765 (EQH38_07135)	1309736..1310092	-	357	WP_001115086.1	SAG1252 family conjugative relaxosome accessory protein	-
EQH38_RS06770 (EQH38_07145)	1310986..1312524	-	1539	WP_001279800.1	UvrD-helicase domain-containing protein	-
EQH38_RS06775 (EQH38_07150)	1312517..1314274	-	1758	WP_000394602.1	AAA family ATPase	-
EQH38_RS06780 (EQH38_07155)	1314264..1315040	-	777	WP_054365402.1	type II toxin-antitoxin system toxin PezT	Toxin
EQH38_RS06785 (EQH38_07160)	1315040..1315516	-	477	WP_000579612.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
EQH38_RS06790 (EQH38_07165)	1315961..1316386	-	426	Protein_1303	hypothetical protein	-
EQH38_RS06795 (EQH38_07170)	1316363..1317096	-	734	Protein_1304	alpha amylase N-terminal ig-like domain-containing protein	-
EQH38_RS06800 (EQH38_07175)	1317259..1318143	-	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
EQH38_RS06805 (EQH38_07180)	1318255..1319109	-	855	WP_000900015.1	ADP-ribosylglycohydrolase family protein	-
EQH38_RS06810 (EQH38_07185)	1319167..1319925	-	759	WP_000262027.1	ATP-grasp domain-containing protein	-
EQH38_RS06815 (EQH38_07190)	1319987..1320175	-	189	WP_000179769.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1163799..1335775	171976

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29700.69 Da
• Isoelectric Point: 7.2008

>T117451 WP_054365402.1 NZ_CP035242:c1315040-1314264 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSSVYDSKENTTSAADVLQELLFGEWSQVEKEML
RVVEERHKELEGKNSYGI

Nucleotide

• Length: 777 bp

>T117451 NZ_CP035242:c1315040-1314264 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTCTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
AGGGTGGTGGAAGAAAGACATAAAGAGTTAGAAGGAAAAAATAGTTATGGAATTTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18245.68 Da
• Isoelectric Point: 4.4188

>AT117451 WP_000579612.1 NZ_CP035242:c1315516-1315040 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT117451 NZ_CP035242:c1315516-1315040 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGCTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTTTCTGATTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Antitoxin

• AlphaFold DB: B6ZCC4