117450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1141382..1141880 Replicon chromosome
Accession NZ_CP035242
Organism Streptococcus pneumoniae strain TVO_1901947

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH38_RS06045 Protein ID WP_001809704.1
Coordinates 1141626..1141880 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH38_RS06040 Protein ID WP_000208080.1
Coordinates 1141382..1141624 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH38_RS10790 1136982..1137107 - 126 WP_001818232.1 hypothetical protein -
EQH38_RS06020 (EQH38_06355) 1137204..1138379 + 1176 WP_000886147.1 A/G-specific adenine glycosylase -
EQH38_RS06025 (EQH38_06360) 1138434..1139138 + 705 WP_000722076.1 response regulator YycF -
EQH38_RS06030 (EQH38_06365) 1139131..1140480 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH38_RS06035 (EQH38_06370) 1140482..1141291 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH38_RS06040 (EQH38_06375) 1141382..1141624 + 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH38_RS06045 (EQH38_06380) 1141626..1141880 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH38_RS06050 (EQH38_06385) 1141955..1143826 + 1872 WP_000150982.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117450 WP_001809704.1 NZ_CP035242:1141626-1141880 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117450 NZ_CP035242:1141626-1141880 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117450 WP_000208080.1 NZ_CP035242:1141382-1141624 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117450 NZ_CP035242:1141382-1141624 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References