Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 628905..629573 Replicon chromosome
Accession NZ_CP035242
Organism Streptococcus pneumoniae strain TVO_1901947

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EQH38_RS03545 Protein ID WP_000930275.1
Coordinates 628905..629084 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH38_RS03550 Protein ID WP_000961810.1
Coordinates 629121..629573 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH38_RS03520 (EQH38_03705) 624781..626100 + 1320 WP_054362602.1 glycoside hydrolase family 32 protein -
EQH38_RS03530 (EQH38_03715) 626644..627915 - 1272 WP_001113216.1 replication-associated recombination protein A -
EQH38_RS03535 (EQH38_03725) 628185..628424 + 240 WP_000818078.1 hypothetical protein -
EQH38_RS03540 (EQH38_03735) 628589..628768 + 180 WP_001048906.1 hypothetical protein -
EQH38_RS03545 (EQH38_03740) 628905..629084 + 180 WP_000930275.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH38_RS03550 (EQH38_03745) 629121..629573 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH38_RS03555 (EQH38_03750) 629864..630334 + 471 WP_000257104.1 DUF3013 family protein -
EQH38_RS03560 (EQH38_03755) 630353..631420 + 1068 WP_000719708.1 site-2 protease family protein -
EQH38_RS03565 (EQH38_03760) 631422..631850 + 429 WP_000402002.1 NUDIX hydrolase -
EQH38_RS03570 (EQH38_03765) 631985..632938 + 954 WP_000970783.1 50S ribosomal protein L11 methyltransferase -
EQH38_RS03575 (EQH38_03770) 632940..633683 + 744 WP_001188198.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6729.99 Da        Isoelectric Point: 11.0174

>T117449 WP_000930275.1 NZ_CP035242:628905-629084 [Streptococcus pneumoniae]
MLMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117449 NZ_CP035242:628905-629084 [Streptococcus pneumoniae]
ATGCTTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117449 WP_000961810.1 NZ_CP035242:629121-629573 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117449 NZ_CP035242:629121-629573 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References