Detailed information of TA system TA117449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 628905..629573
• Replicon: chromosome
• Accession: NZ_CP035242
• Organism: Streptococcus pneumoniae strain TVO_1901947

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EQH38_RS03545
• Protein ID: WP_000930275.1
• Coordinates: 628905..629084 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: EQH38_RS03550
• Protein ID: WP_000961810.1
• Coordinates: 629121..629573 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH38_RS03520 (EQH38_03705)	624781..626100	+	1320	WP_054362602.1	glycoside hydrolase family 32 protein	-
EQH38_RS03530 (EQH38_03715)	626644..627915	-	1272	WP_001113216.1	replication-associated recombination protein A	-
EQH38_RS03535 (EQH38_03725)	628185..628424	+	240	WP_000818078.1	hypothetical protein	-
EQH38_RS03540 (EQH38_03735)	628589..628768	+	180	WP_001048906.1	hypothetical protein	-
EQH38_RS03545 (EQH38_03740)	628905..629084	+	180	WP_000930275.1	type II toxin-antitoxin system HicA family toxin	Toxin
EQH38_RS03550 (EQH38_03745)	629121..629573	+	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EQH38_RS03555 (EQH38_03750)	629864..630334	+	471	WP_000257104.1	DUF3013 family protein	-
EQH38_RS03560 (EQH38_03755)	630353..631420	+	1068	WP_000719708.1	site-2 protease family protein	-
EQH38_RS03565 (EQH38_03760)	631422..631850	+	429	WP_000402002.1	NUDIX hydrolase	-
EQH38_RS03570 (EQH38_03765)	631985..632938	+	954	WP_000970783.1	50S ribosomal protein L11 methyltransferase	-
EQH38_RS03575 (EQH38_03770)	632940..633683	+	744	WP_001188198.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6729.99 Da
• Isoelectric Point: 11.0174

>T117449 WP_000930275.1 NZ_CP035242:628905-629084 [Streptococcus pneumoniae]
MLMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Nucleotide

• Length: 180 bp

>T117449 NZ_CP035242:628905-629084 [Streptococcus pneumoniae]
ATGCTTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT117449 WP_000961810.1 NZ_CP035242:629121-629573 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT117449 NZ_CP035242:629121-629573 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: G0IC64