Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1545509..1546177 Replicon chromosome
Accession NZ_CP035241
Organism Streptococcus pneumoniae strain TVO_1901948

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag EQH39_RS07725 Protein ID WP_001132284.1
Coordinates 1545998..1546177 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH39_RS07720 Protein ID WP_000961810.1
Coordinates 1545509..1545961 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH39_RS07695 (EQH39_08110) 1541401..1542144 - 744 WP_001188212.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
EQH39_RS07700 (EQH39_08115) 1542146..1543096 - 951 WP_000451152.1 50S ribosomal protein L11 methyltransferase -
EQH39_RS07705 (EQH39_08120) 1543232..1543660 - 429 WP_000418174.1 NUDIX hydrolase -
EQH39_RS07710 (EQH39_08125) 1543641..1544729 - 1089 WP_000719713.1 site-2 protease family protein -
EQH39_RS07715 (EQH39_08130) 1544748..1545218 - 471 WP_000257086.1 DUF3013 family protein -
EQH39_RS07720 (EQH39_08135) 1545509..1545961 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH39_RS07725 (EQH39_08140) 1545998..1546177 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH39_RS07730 (EQH39_08145) 1546314..1546493 - 180 WP_001048906.1 hypothetical protein -
EQH39_RS07735 (EQH39_08155) 1546658..1546879 - 222 WP_000425689.1 hypothetical protein -
EQH39_RS07740 (EQH39_08160) 1547171..1548442 + 1272 WP_001113212.1 replication-associated recombination protein A -
EQH39_RS07750 (EQH39_08170) 1548987..1550306 - 1320 WP_000502556.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T117448 WP_001132284.1 NZ_CP035241:c1546177-1545998 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117448 NZ_CP035241:c1546177-1545998 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117448 WP_000961810.1 NZ_CP035241:c1545961-1545509 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117448 NZ_CP035241:c1545961-1545509 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGGCTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References