Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1080011..1080509 Replicon chromosome
Accession NZ_CP035241
Organism Streptococcus pneumoniae strain TVO_1901948

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH39_RS05310 Protein ID WP_001809704.1
Coordinates 1080011..1080265 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH39_RS05315 Protein ID WP_000208080.1
Coordinates 1080267..1080509 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH39_RS05295 (EQH39_05600) 1075272..1077740 - 2469 WP_001152992.1 DNA gyrase subunit A -
EQH39_RS05300 (EQH39_05605) 1077934..1078920 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH39_RS05305 (EQH39_05610) 1079269..1079964 - 696 WP_000731162.1 potassium channel family protein -
EQH39_RS05310 (EQH39_05615) 1080011..1080265 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH39_RS05315 (EQH39_05620) 1080267..1080509 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH39_RS05320 (EQH39_05625) 1080600..1081409 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH39_RS05325 (EQH39_05630) 1081411..1082760 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH39_RS05330 (EQH39_05635) 1082753..1083457 - 705 WP_000722076.1 response regulator YycF -
EQH39_RS05335 (EQH39_05640) 1083512..1084687 - 1176 WP_000886153.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117446 WP_001809704.1 NZ_CP035241:c1080265-1080011 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117446 NZ_CP035241:c1080265-1080011 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117446 WP_000208080.1 NZ_CP035241:c1080509-1080267 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117446 NZ_CP035241:c1080509-1080267 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGATTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References