Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1156976..1157474 Replicon chromosome
Accession NZ_CP035239
Organism Streptococcus pneumoniae strain TVO_TIGR4

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH41_RS05695 Protein ID WP_001809704.1
Coordinates 1156976..1157230 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH41_RS05700 Protein ID WP_000208080.1
Coordinates 1157232..1157474 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH41_RS05690 (EQH41_06045) 1155030..1156901 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
EQH41_RS05695 (EQH41_06050) 1156976..1157230 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH41_RS05700 (EQH41_06055) 1157232..1157474 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH41_RS05705 (EQH41_06060) 1157565..1158374 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH41_RS05710 (EQH41_06065) 1158376..1159725 - 1350 WP_000886219.1 cell wall metabolism sensor histidine kinase VicK -
EQH41_RS05715 (EQH41_06070) 1159718..1160422 - 705 WP_000722076.1 response regulator YycF -
EQH41_RS05720 (EQH41_06075) 1160478..1161653 - 1176 WP_000886146.1 A/G-specific adenine glycosylase -
EQH41_RS10910 1161750..1161875 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117443 WP_001809704.1 NZ_CP035239:c1157230-1156976 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117443 NZ_CP035239:c1157230-1156976 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117443 WP_000208080.1 NZ_CP035239:c1157474-1157232 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117443 NZ_CP035239:c1157474-1157232 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References