Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1112845..1113343 Replicon chromosome
Accession NZ_CP035238
Organism Streptococcus pneumoniae strain TVO_D39

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH42_RS05475 Protein ID WP_001809704.1
Coordinates 1112845..1113099 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH42_RS05480 Protein ID WP_000208080.1
Coordinates 1113101..1113343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH42_RS05470 (EQH42_05780) 1110899..1112770 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
EQH42_RS05475 (EQH42_05785) 1112845..1113099 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH42_RS05480 (EQH42_05790) 1113101..1113343 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH42_RS05485 (EQH42_05795) 1113434..1114243 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH42_RS05490 (EQH42_05800) 1114245..1115594 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH42_RS05495 (EQH42_05805) 1115587..1116291 - 705 WP_000722076.1 response regulator YycF -
EQH42_RS05500 (EQH42_05810) 1116346..1117521 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117438 WP_001809704.1 NZ_CP035238:c1113099-1112845 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117438 NZ_CP035238:c1113099-1112845 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117438 WP_000208080.1 NZ_CP035238:c1113343-1113101 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117438 NZ_CP035238:c1113343-1113101 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References