Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1628358..1629026 Replicon chromosome
Accession NZ_CP035236
Organism Streptococcus pneumoniae strain TVO_1902282

Toxin (Protein)


Gene name hicA Uniprot ID I0T4C6
Locus tag EQH44_RS08120 Protein ID WP_001132287.1
Coordinates 1628847..1629026 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH44_RS08115 Protein ID WP_000961810.1
Coordinates 1628358..1628810 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH44_RS08095 (EQH44_08570) 1625207..1626241 - 1035 WP_000747915.1 ATP-binding protein -
EQH44_RS08100 (EQH44_08575) 1626351..1626509 - 159 WP_000401986.1 7,8-dihydro-8-oxoguanine-triphosphatase -
EQH44_RS08105 (EQH44_08580) 1626511..1627578 - 1068 WP_000719703.1 site-2 protease family protein -
EQH44_RS08110 (EQH44_08585) 1627597..1628067 - 471 WP_000257083.1 DUF3013 family protein -
EQH44_RS08115 (EQH44_08590) 1628358..1628810 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH44_RS08120 (EQH44_08595) 1628847..1629026 - 180 WP_001132287.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH44_RS08125 (EQH44_08600) 1629163..1629342 - 180 WP_001810816.1 hypothetical protein -
EQH44_RS08130 (EQH44_08610) 1629507..1629746 - 240 WP_000818079.1 hypothetical protein -
EQH44_RS08135 (EQH44_08620) 1630016..1631287 + 1272 WP_001113214.1 replication-associated recombination protein A -
EQH44_RS08145 (EQH44_08630) 1631834..1633153 - 1320 WP_000502537.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6697.91 Da        Isoelectric Point: 11.0174

>T117434 WP_001132287.1 NZ_CP035236:c1629026-1628847 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117434 NZ_CP035236:c1629026-1628847 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGTTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACCTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117434 WP_000961810.1 NZ_CP035236:c1628810-1628358 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117434 NZ_CP035236:c1628810-1628358 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCCACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGATGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0T4C6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References