Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1143916..1144414 Replicon chromosome
Accession NZ_CP035236
Organism Streptococcus pneumoniae strain TVO_1902282

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag EQH44_RS05685 Protein ID WP_001809704.1
Coordinates 1143916..1144170 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH44_RS05690 Protein ID WP_000208080.1
Coordinates 1144172..1144414 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH44_RS05670 (EQH44_06005) 1139309..1141777 - 2469 WP_001152989.1 DNA gyrase subunit A -
EQH44_RS05675 (EQH44_06010) 1141971..1142957 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH44_RS05680 (EQH44_06015) 1143217..1143869 - 653 Protein_1135 ion transporter -
EQH44_RS05685 (EQH44_06020) 1143916..1144170 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH44_RS05690 (EQH44_06025) 1144172..1144414 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH44_RS05695 (EQH44_06030) 1144505..1145314 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH44_RS05700 (EQH44_06035) 1145316..1146665 - 1350 WP_061645482.1 cell wall metabolism sensor histidine kinase VicK -
EQH44_RS05705 (EQH44_06040) 1146658..1147362 - 705 WP_000722076.1 response regulator YycF -
EQH44_RS05710 (EQH44_06045) 1147417..1148592 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
EQH44_RS10725 1148689..1148814 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T117432 WP_001809704.1 NZ_CP035236:c1144170-1143916 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117432 NZ_CP035236:c1144170-1143916 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117432 WP_000208080.1 NZ_CP035236:c1144414-1144172 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117432 NZ_CP035236:c1144414-1144172 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References