Detailed information of TA system TA117430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 592530..593148
• Replicon: chromosome
• Accession: NZ_CP035236
• Organism: Streptococcus pneumoniae strain TVO_1902282

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A4F7JJU4
• Locus tag: EQH44_RS02985
• Protein ID: WP_000385025.1
• Coordinates: 592530..592898 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0I9CGM3
• Locus tag: EQH44_RS02990
• Protein ID: WP_000105960.1
• Coordinates: 592888..593148 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQH44_RS02950 (EQH44_03155)	587889..588359	+	471	WP_000335587.1	HIT family protein	-
EQH44_RS02955 (EQH44_03160)	588362..589078	+	717	WP_000747771.1	LD-carboxypeptidase LdcB/DacB	-
EQH44_RS02960	589118..589255	-	138	WP_001809964.1	hypothetical protein	-
EQH44_RS02965 (EQH44_03165)	589387..589812	+	426	WP_001085809.1	50S ribosomal protein L11	-
EQH44_RS02970 (EQH44_03170)	590020..590709	+	690	WP_001085675.1	50S ribosomal protein L1	-
EQH44_RS02975	591301..591582	-	282	WP_061756652.1	hypothetical protein	-
EQH44_RS02980 (EQH44_03180)	591596..591958	+	363	WP_000895070.1	protein-export chaperone SecB	-
EQH44_RS02985 (EQH44_03190)	592530..592898	-	369	WP_000385025.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EQH44_RS02990 (EQH44_03195)	592888..593148	-	261	WP_000105960.1	hypothetical protein	Antitoxin
EQH44_RS02995 (EQH44_03200)	593473..594465	+	993	WP_001240806.1	ATP-binding cassette domain-containing protein	-
EQH44_RS03000 (EQH44_03205)	594467..595285	+	819	WP_000594189.1	ABC-2 family transporter protein	-
EQH44_RS03005 (EQH44_03210)	595287..596072	+	786	WP_000760712.1	ABC transporter permease	-
EQH44_RS03010 (EQH44_03215)	596111..596389	+	279	WP_001812029.1	hypothetical protein	-
EQH44_RS03015 (EQH44_03220)	596374..596571	+	198	WP_001812028.1	hypothetical protein	-
EQH44_RS03020	596889..597026	-	138	WP_001827249.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14633.92 Da
• Isoelectric Point: 8.0387

>T117430 WP_000385025.1 NZ_CP035236:c592898-592530 [Streptococcus pneumoniae]
MDYKVRFTEQARQDLDDIFIYYSTEFSENIAKKVITRLQQITNLLIFSPEGGISFDHKIGYSLYPENMLRMIVSKQYLLF
YLIHEKEVHTLRIINSRTDYLNQLDHLFRTCRKLFSSQIISL

Nucleotide

• Length: 369 bp

>T117430 NZ_CP035236:c592898-592530 [Streptococcus pneumoniae]
ATGGACTATAAAGTACGCTTCACAGAACAAGCCAGACAAGACTTAGACGATATCTTCATCTACTACTCCACAGAGTTCAG
TGAAAACATAGCCAAGAAAGTCATCACTCGTCTACAACAAATTACCAACCTACTCATCTTCTCACCAGAGGGCGGTATTA
GCTTTGATCATAAAATCGGATACTCCCTCTATCCAGAAAATATGCTCAGAATGATTGTCTCTAAACAATACCTGCTCTTT
TACCTCATTCATGAAAAAGAAGTCCATACCCTGAGAATTATCAACTCACGCACCGACTACCTAAACCAACTCGACCACCT
CTTTCGTACATGTAGGAAACTATTTTCCTCACAAATAATCTCATTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9809.13 Da
• Isoelectric Point: 4.3322

>AT117430 WP_000105960.1 NZ_CP035236:c593148-592888 [Streptococcus pneumoniae]
MSTLTRDRVYNFCVNTQLFEEAKTILESKNISLSDALNLFVEQIVLEKGLTIKTADQPKAELDKGYQDIIEGRLYDADEV
FSKYGL

Nucleotide

• Length: 261 bp

>AT117430 NZ_CP035236:c593148-592888 [Streptococcus pneumoniae]
ATGTCAACACTTACACGAGACCGAGTTTATAACTTCTGCGTCAATACTCAACTATTTGAAGAAGCAAAAACCATCCTAGA
AAGCAAAAACATCAGCCTTTCAGATGCCCTCAACCTCTTTGTAGAACAAATCGTCCTTGAAAAAGGTCTAACAATTAAAA
CAGCCGACCAACCCAAAGCAGAACTAGATAAAGGCTACCAAGATATCATCGAAGGGCGTCTCTACGACGCAGACGAGGTC
TTTTCAAAGTATGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4F7JJU4

Antitoxin

• AlphaFold DB: A0A0I9CGM3