Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1671413..1672081 Replicon chromosome
Accession NZ_CP035235
Organism Streptococcus pneumoniae strain TVO_1902276

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag EQH45_RS08435 Protein ID WP_001132282.1
Coordinates 1671902..1672081 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH45_RS08430 Protein ID WP_000961810.1
Coordinates 1671413..1671865 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH45_RS08405 (EQH45_08840) 1666451..1668694 - 2244 WP_001094321.1 S8 family serine peptidase -
EQH45_RS08410 (EQH45_08845) 1668696..1669730 - 1035 WP_000747915.1 ATP-binding protein -
EQH45_RS08415 (EQH45_08850) 1669840..1670004 - 165 WP_000421870.1 hypothetical protein -
EQH45_RS08420 (EQH45_08855) 1670054..1670596 - 543 WP_000891119.1 hypothetical protein -
EQH45_RS08425 (EQH45_08860) 1670652..1671122 - 471 WP_000257102.1 DUF3013 family protein -
EQH45_RS08430 (EQH45_08865) 1671413..1671865 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH45_RS08435 (EQH45_08870) 1671902..1672081 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH45_RS08440 (EQH45_08875) 1672218..1672397 - 180 WP_001048906.1 hypothetical protein -
EQH45_RS08445 (EQH45_08885) 1672601..1672801 - 201 WP_000818077.1 hypothetical protein -
EQH45_RS08450 (EQH45_08895) 1673071..1674342 + 1272 WP_001113214.1 replication-associated recombination protein A -
EQH45_RS08460 (EQH45_08905) 1674889..1676208 - 1320 WP_000502537.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T117429 WP_001132282.1 NZ_CP035235:c1672081-1671902 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117429 NZ_CP035235:c1672081-1671902 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117429 WP_000961810.1 NZ_CP035235:c1671865-1671413 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117429 NZ_CP035235:c1671865-1671413 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGAATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References