Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 922645..923143 Replicon chromosome
Accession NZ_CP035235
Organism Streptococcus pneumoniae strain TVO_1902276

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQH45_RS04635 Protein ID WP_001823540.1
Coordinates 922889..923143 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH45_RS04630 Protein ID WP_000208080.1
Coordinates 922645..922887 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH45_RS11075 918245..918370 - 126 WP_001818232.1 hypothetical protein -
EQH45_RS04610 (EQH45_04865) 918467..919642 + 1176 WP_238124959.1 A/G-specific adenine glycosylase -
EQH45_RS04615 (EQH45_04870) 919697..920401 + 705 WP_000722076.1 response regulator YycF -
EQH45_RS04620 (EQH45_04875) 920394..921743 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH45_RS04625 (EQH45_04880) 921745..922554 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH45_RS04630 (EQH45_04885) 922645..922887 + 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH45_RS04635 (EQH45_04890) 922889..923143 + 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH45_RS04640 (EQH45_04895) 923190..923885 + 696 WP_000731163.1 potassium channel family protein -
EQH45_RS04645 (EQH45_04900) 924234..925220 - 987 WP_000204727.1 L-lactate dehydrogenase -
EQH45_RS04650 (EQH45_04905) 925414..927882 + 2469 WP_001152992.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T117427 WP_001823540.1 NZ_CP035235:922889-923143 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117427 NZ_CP035235:922889-923143 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117427 WP_000208080.1 NZ_CP035235:922645-922887 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117427 NZ_CP035235:922645-922887 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References