Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1633261..1633929 Replicon chromosome
Accession NZ_CP035234
Organism Streptococcus pneumoniae strain TVO_1902277

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag EQH46_RS08235 Protein ID WP_001132282.1
Coordinates 1633750..1633929 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag EQH46_RS08230 Protein ID WP_000961810.1
Coordinates 1633261..1633713 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH46_RS08205 (EQH46_08620) 1628299..1630542 - 2244 WP_001094321.1 S8 family serine peptidase -
EQH46_RS08210 (EQH46_08625) 1630544..1631578 - 1035 WP_000747915.1 ATP-binding protein -
EQH46_RS08215 (EQH46_08630) 1631688..1631852 - 165 WP_000421870.1 hypothetical protein -
EQH46_RS08220 (EQH46_08635) 1631902..1632444 - 543 WP_000891119.1 hypothetical protein -
EQH46_RS08225 (EQH46_08640) 1632500..1632970 - 471 WP_000257102.1 DUF3013 family protein -
EQH46_RS08230 (EQH46_08645) 1633261..1633713 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EQH46_RS08235 (EQH46_08650) 1633750..1633929 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
EQH46_RS08240 (EQH46_08655) 1634066..1634245 - 180 WP_001048906.1 hypothetical protein -
EQH46_RS08245 (EQH46_08665) 1634449..1634649 - 201 WP_000818077.1 hypothetical protein -
EQH46_RS08250 (EQH46_08675) 1634919..1636190 + 1272 WP_001113214.1 replication-associated recombination protein A -
EQH46_RS08260 (EQH46_08685) 1636737..1638056 - 1320 WP_000502537.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T117426 WP_001132282.1 NZ_CP035234:c1633929-1633750 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T117426 NZ_CP035234:c1633929-1633750 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT117426 WP_000961810.1 NZ_CP035234:c1633713-1633261 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT117426 NZ_CP035234:c1633713-1633261 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References