Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1160286..1160784 Replicon chromosome
Accession NZ_CP035234
Organism Streptococcus pneumoniae strain TVO_1902277

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag EQH46_RS05800 Protein ID WP_001823540.1
Coordinates 1160286..1160540 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag EQH46_RS05805 Protein ID WP_000208080.1
Coordinates 1160542..1160784 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH46_RS05785 (EQH46_06085) 1155547..1158015 - 2469 WP_001152992.1 DNA gyrase subunit A -
EQH46_RS05790 (EQH46_06090) 1158209..1159195 + 987 WP_000204727.1 L-lactate dehydrogenase -
EQH46_RS05795 (EQH46_06095) 1159544..1160239 - 696 WP_000731163.1 potassium channel family protein -
EQH46_RS05800 (EQH46_06100) 1160286..1160540 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH46_RS05805 (EQH46_06105) 1160542..1160784 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
EQH46_RS05810 (EQH46_06110) 1160875..1161684 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
EQH46_RS05815 (EQH46_06115) 1161686..1163035 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
EQH46_RS05820 (EQH46_06120) 1163028..1163732 - 705 WP_000722076.1 response regulator YycF -
EQH46_RS05825 (EQH46_06125) 1163787..1164962 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
EQH46_RS10885 1165059..1165184 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T117425 WP_001823540.1 NZ_CP035234:c1160540-1160286 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T117425 NZ_CP035234:c1160540-1160286 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT117425 WP_000208080.1 NZ_CP035234:c1160784-1160542 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT117425 NZ_CP035234:c1160784-1160542 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References