Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1119640..1120133 Replicon chromosome
Accession NZ_CP035220
Organism Enterococcus faecium strain SRCM103470

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag EQV91_RS05785 Protein ID WP_002329323.1
Coordinates 1119867..1120133 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag EQV91_RS05780 Protein ID WP_002329324.1
Coordinates 1119640..1119870 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQV91_RS05745 1115117..1115443 + 327 Protein_1080 hypothetical protein -
EQV91_RS05750 1115518..1116674 + 1157 WP_119364684.1 IS3 family transposase -
EQV91_RS05755 1117133..1117723 - 591 WP_002329329.1 glutamine amidotransferase -
EQV91_RS05760 1118511..1118816 + 306 WP_002342565.1 hypothetical protein -
EQV91_RS05765 1118829..1119164 + 336 WP_002329326.1 hypothetical protein -
EQV91_RS05780 1119640..1119870 + 231 WP_002329324.1 hypothetical protein Antitoxin
EQV91_RS05785 1119867..1120133 + 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQV91_RS05790 1120428..1120616 + 189 WP_047927277.1 hypothetical protein -
EQV91_RS05795 1120632..1121798 + 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
EQV91_RS05800 1122031..1123074 + 1044 WP_047927280.1 heat-inducible transcriptional repressor HrcA -
EQV91_RS05805 1123168..1123731 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T117402 WP_002329323.1 NZ_CP035220:1119867-1120133 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T117402 NZ_CP035220:1119867-1120133 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT117402 WP_002329324.1 NZ_CP035220:1119640-1119870 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT117402 NZ_CP035220:1119640-1119870 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References