Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4697827..4698484 Replicon chromosome
Accession NZ_CP035207
Organism Klebsiella quasipneumoniae strain TH114

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EQH50_RS22920 Protein ID WP_002916310.1
Coordinates 4698074..4698484 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EQH50_RS22915 Protein ID WP_002916312.1
Coordinates 4697827..4698093 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH50_RS22895 4694275..4695003 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
EQH50_RS22900 4695054..4695365 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EQH50_RS22905 4695528..4696187 + 660 WP_004205319.1 hemolysin III family protein -
EQH50_RS22910 4696598..4697581 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
EQH50_RS22915 4697827..4698093 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EQH50_RS22920 4698074..4698484 + 411 WP_002916310.1 protein YgfX Toxin
EQH50_RS22925 4698491..4699012 - 522 WP_130939397.1 flavodoxin FldB -
EQH50_RS22930 4699113..4700009 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EQH50_RS22935 4700032..4700745 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EQH50_RS22940 4700751..4702484 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T117382 WP_002916310.1 NZ_CP035207:4698074-4698484 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T117382 NZ_CP035207:4698074-4698484 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT117382 WP_002916312.1 NZ_CP035207:4697827-4698093 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT117382 NZ_CP035207:4697827-4698093 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References